US 11,926,633 B2
Synthesis methods for upadacitinib and intermediate thereof
Peng Wang, Suzhou (CN); Pixu Li, Suzhou (CN); Qiang Wei, Suzhou (CN); Wen Cheng, Suzhou (CN); and Hao Wu, Suzhou (CN)
Assigned to SUZHOU PENGXU PHARMATECH CO., LTD, Suzhou (CN)
Appl. No. 17/272,369
Filed by SUZHOU PENGXU PHARMATECH CO., LTD, Suzhou (CN)
PCT Filed Aug. 26, 2019, PCT No. PCT/CN2019/102443
§ 371(c)(1), (2) Date Mar. 1, 2021,
PCT Pub. No. WO2020/043033, PCT Pub. Date Mar. 5, 2020.
Claims priority of application No. 201811008444.4 (CN), filed on Aug. 31, 2018; and application No. 201811083531.6 (CN), filed on Sep. 17, 2018.
Prior Publication US 2021/0323971 A1, Oct. 21, 2021
Int. Cl. C07D 487/14 (2006.01); C07D 207/08 (2006.01); C07D 207/16 (2006.01); C07D 241/20 (2006.01); C07D 487/04 (2006.01)
CPC C07D 487/14 (2013.01) [C07D 207/08 (2013.01); C07D 207/16 (2013.01); C07D 241/20 (2013.01); C07D 487/04 (2013.01)] 2 Claims
 
1. A compound, having a structure shown Formula III:

OG Complex Work Unit Chemistry
wherein, R is a protective group of nitrogen atoms.