US 11,926,618 B2
Halogen-substituted phenylate compound and applications thereof
Wu Du, Sichuan (CN); Yu Li, Sichuan (CN); Haibo Li, Sichuan (CN); Yuanwei Chen, Sichuan (CN); Chengzhi Zhang, Sichuan (CN); and Xinghai Li, Sichuan (CN)
Assigned to HINOVA PHARMACEUTICALS INC., Sichuan (CN)
Appl. No. 17/753,162
Filed by HINOVA PHARMACEUTICALS INC., Sichuan (CN)
PCT Filed Aug. 20, 2020, PCT No. PCT/CN2020/110252
§ 371(c)(1), (2) Date Feb. 22, 2022,
PCT Pub. No. WO2021/032161, PCT Pub. Date Feb. 25, 2021.
Claims priority of application No. 201910774991.1 (CN), filed on Aug. 21, 2019.
Prior Publication US 2022/0332707 A1, Oct. 20, 2022
Int. Cl. C07D 403/12 (2006.01); A61K 31/53 (2006.01); A61P 1/16 (2006.01); A61P 3/04 (2006.01); A61P 3/06 (2006.01); A61P 3/10 (2006.01); A61P 5/14 (2006.01); A61P 5/16 (2006.01); A61P 9/10 (2006.01); C07D 253/075 (2006.01)
CPC C07D 403/12 (2013.01) [C07B 2200/05 (2013.01)] 11 Claims
 
1. The compound represented by formula (I), or an optical isomer thereof, or a salt thereof:

OG Complex Work Unit Chemistry
wherein, each of R1-R7, R9, and R10 is independently selected from H and D; A is selected from the group consisting of CH and CD; B is N; X and Y are each independently selected from the group consisting of Cl and Br; X and Y are not Cl at the same time.