CPC C07D 401/14 (2013.01) [C07D 403/04 (2013.01); C07D 403/14 (2013.01); C07D 405/14 (2013.01); C07D 409/14 (2013.01); C07D 417/04 (2013.01); C07D 417/14 (2013.01); C07D 471/04 (2013.01); C07D 487/04 (2013.01); C07D 491/048 (2013.01); C07D 495/04 (2013.01); C07B 2200/07 (2013.01)] | 23 Claims |
1. A compound of general formula (I), or a tautomer, stereoisomer, pharmaceutically acceptable salt or pro-drug thereof:
wherein:
a dashed line indicates an optional bond;
X represents:
a 5- or 6-membered, unsaturated heterocyclic group optionally substituted by one or more substituents independently selected from halogen, C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy, —CN, —NO2, —N(R)2, and —SO2R (where each R is independently H or C1-6 alkyl;
a C3-5 cycloalkyl group optionally substituted by one or more substituents independently selected from C1-6 alkyl, C1-6 haloalkyl, and C1-6 alkoxy; or
an aryl group optionally substituted by one or more substituents independently selected from halogen, C1-6 alkyl, C1-6 haloalkyl, and C1-6 alkoxy;
Y represents:
an aryl or heteroaryl group optionally substituted by one or more substituents independently selected from halogen, C1-6 alkyl, C1-6 haloalkyl, and C1-6 alkoxy;
a 5- or 6-membered, saturated heterocyclic group optionally substituted by one or more substituents independently selected from C1-6 alkyl, C1-6 haloalkyl, and C1-6 alkoxy; or
a C3-6 cycloalkyl group optionally substituted by one or more substituents independently selected from C1-6 alkyl, C1-6 haloalkyl, and C1-6 alkoxy; and
Z represents:
an aryl group optionally substituted by one or more substituents independently selected from halogen, C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy, CN, —NO2,
—N2, and —SO2R (where each R is independently H or C1-6 alkyl; or
an unsaturated, 5- to 10-membered mono- or bicyclic heterocyclic group optionally substituted by one or more substituents independently selected from halogen, C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy, —CN, —NO2, —N(R)2, and
—SO2R (where each R is independently H or C1-6 alkyl.
|