US 11,926,608 B2
Synthesis method and device for rapidly producing lactide at high yield
Wei Jiang, Nanjing (CN); Yunbiao Qi, Nanjing (CN); Ping Sun, Nanjing (CN); Wei Huang, Nanjing (CN); Aimin Li, Nanjing (CN); and Quanxing Zhang, Nanjing (CN)
Assigned to NANJING UNIVERSITY, Nanjing (CN); and NANJING QUANKAI RESEARCH INSTITUTE OF BIOMATERIALS CO., LTD., Nanjing (CN)
Filed by NANJING UNIVERSITY, Nanjing (CN); and NANJING QUANKAI RESEARCH INSTITUTE OF BIOMATERIALS CO., LTD., Nanjing (CN)
Filed on Mar. 4, 2021, as Appl. No. 17/249,524.
Prior Publication US 2021/0188799 A1, Jun. 24, 2021
Int. Cl. C07D 319/12 (2006.01); B01D 1/22 (2006.01); B01D 3/14 (2006.01); B01D 5/00 (2006.01); B01J 4/00 (2006.01); B01J 19/00 (2006.01); B01J 19/24 (2006.01); C08G 63/91 (2006.01)
CPC C07D 319/12 (2013.01) [B01D 1/22 (2013.01); B01D 3/143 (2013.01); B01D 5/006 (2013.01); B01D 5/0075 (2013.01); B01D 5/009 (2013.01); B01J 4/001 (2013.01); B01J 19/0013 (2013.01); B01J 19/245 (2013.01); C08G 63/912 (2013.01); B01J 2219/0004 (2013.01); B01J 2219/00081 (2013.01); B01J 2219/00085 (2013.01)] 12 Claims
OG exemplary drawing
 
1. A synthesis device for rapidly producing lactide at high yield, comprising:
an oligomer preparation system (I) used for carrying out a polymerization synthesis reaction with L-lactic acid, D-lactic acid, or DL-lactic acid as a raw material, so as to obtain oligolactic acid, and introducing a reaction product into an oligomer purification system (II);
the oligomer purification system (II) used for purifying the reaction product introduced from the oligomer preparation system (I), removing unreacted lactic acid and water, and introducing the purified oligolactic acid into an oligomer depolymerization system (III);
the oligomer depolymerization system (III) used for depolymerizing the purified oligolactic acid under an action of a catalyst, so as to obtain crude lactide, and introducing the crude lactide into a lactide purification system (IV);
the lactide purification system (IV) used for purifying the crude lactide, so as to obtain a lactide product and a by-product, and introducing the by-product into a recovery system (V); and
the recovery system (V) used for processing and utilizing the by-product.