US 11,925,790 B2
Processes and devices for delivery of fluid by chemical reaction
William Godwin Atterbury, Columbus, OH (US); Corrie Jo Bennison, Lewis Center, OH (US); Robert Jonathan Cain, Lewis Center, OH (US); Michael Funk Chiappetta, Greenwood, IN (US); Jeffrey Leclair Ellis, Columbus, OH (US); David Arthur Holley, Lancaster, OH (US); Mark Lafever, Indianapolis, IN (US); Beverly Ann Piatt, Columbus, OH (US); and John Paul Tallarico, Powell, OH (US)
Assigned to Eli Lilly and Company, Indianapolis, IN (US)
Appl. No. 16/484,676
Filed by Eli Lilly and Company, Indianapolis, IN (US)
PCT Filed Feb. 9, 2018, PCT No. PCT/US2018/017547
§ 371(c)(1), (2) Date Aug. 8, 2019,
PCT Pub. No. WO2018/152018, PCT Pub. Date Aug. 23, 2018.
Claims priority of provisional application 62/460,414, filed on Feb. 17, 2017.
Prior Publication US 2020/0030537 A1, Jan. 30, 2020
Int. Cl. A61M 5/20 (2006.01); A61M 5/31 (2006.01)
CPC A61M 5/2046 (2013.01) [A61M 2005/2073 (2013.01); A61M 2005/3125 (2013.01); A61M 2205/0216 (2013.01); A61M 2205/7536 (2013.01)] 23 Claims
OG exemplary drawing
 
1. A device for delivering a therapeutic fluid by chemical reaction, the device comprising:
a barrel having a first chamber, a second chamber, and a third chamber;
a piston positioned between the first and second chambers of the barrel;
a spring configured to move the piston;
a plunger positioned between the second and third chambers of the barrel; and
an actuator having:
a locked configuration in which the actuator is prevented from moving axially relative to the barrel;
an unlocked configuration in which the actuator is capable of moving axially relative to the barrel; and
a delivery configuration in which the actuator moves axially relative to the barrel;
wherein:
in the locked and unlocked configurations, the first chamber contains a first reagent, the second chamber contains a second reagent and is separated from the first chamber by the piston, and the third chamber contains the therapeutic fluid; and
in the delivery configuration, the spring moves the piston to place the first chamber in communication with the second chamber such that the first and second reagents react to generate a gas that drives the plunger to deliver the therapeutic fluid from the third chamber,
the device further comprising a C-shaped ring that holds the actuator downward relative to the barrel in the delivery configuration to prevent the actuator from returning upward to the unlocked configuration.