US 11,925,723 B2
Bone implant and systems and coatings for the controllable release of antimicrobial metal ions
Houdin Dehnad, El Granada, CA (US); Paul E. Chirico, Campbell, CA (US); Bohdan Wolodymyr Chopko, Henderson, NV (US); John Barr, San Diego, CA (US); Robert Vincent McCormick, Saratoga, CA (US); Julie Lucero, San Jose, CA (US); and Jason A. Jegge, San Jose, CA (US)
Assigned to Silver Bullet Therapeutics, Inc., San Jose, CA (US)
Filed by Silver Bullet Therapeutics, Inc., San Jose, CA (US)
Filed on Jun. 1, 2021, as Appl. No. 17/336,246.
Application 13/748,546 is a division of application No. 13/231,219, filed on Sep. 13, 2011, granted, now 8,771,323, issued on Jul. 8, 2014.
Application 17/336,246 is a continuation of application No. 16/391,195, filed on Apr. 22, 2019, granted, now 11,020,508.
Application 16/391,195 is a continuation of application No. 15/820,393, filed on Nov. 21, 2017, granted, now 10,265,435, issued on Apr. 23, 2019.
Application 15/820,393 is a continuation in part of application No. 14/833,569, filed on Aug. 24, 2015, granted, now 9,821,094, issued on Nov. 21, 2017.
Application 14/833,569 is a continuation in part of application No. 14/679,893, filed on Apr. 6, 2015, granted, now 9,114,197, issued on Aug. 25, 2015.
Application 14/679,893 is a continuation in part of application No. 14/569,545, filed on Dec. 12, 2014, granted, now 8,999,367, issued on Apr. 7, 2015.
Application 14/569,545 is a continuation of application No. 14/302,352, filed on Jun. 11, 2014, granted, now 8,927,004, issued on Jan. 6, 2015.
Application 15/820,393 is a continuation in part of application No. 14/801,732, filed on Jul. 16, 2015, granted, now 9,889,284, issued on Feb. 13, 2018.
Application 14/801,732 is a continuation of application No. 13/748,546, filed on Jan. 23, 2013, granted, now 9,108,051, issued on Aug. 18, 2015.
Application 14/801,732 is a continuation in part of application No. 13/527,389, filed on Jun. 19, 2012, granted, now 9,248,254, issued on Feb. 2, 2016.
Application 13/527,389 is a continuation of application No. 12/870,082, filed on Aug. 27, 2010, granted, now 8,221,396, issued on Jul. 17, 2012.
Claims priority of provisional application 62/059,714, filed on Oct. 3, 2014.
Claims priority of provisional application 61/413,230, filed on Nov. 12, 2010.
Claims priority of provisional application 61/438,162, filed on Jan. 31, 2011.
Claims priority of provisional application 61/447,393, filed on Feb. 28, 2011.
Claims priority of provisional application 61/465,350, filed on Mar. 18, 2011.
Claims priority of provisional application 61/516,388, filed on Apr. 4, 2011.
Claims priority of provisional application 61/237,506, filed on Aug. 27, 2009.
Claims priority of provisional application 61/340,587, filed on Mar. 19, 2010.
Claims priority of provisional application 61/359,549, filed on Jun. 29, 2010.
Prior Publication US 2021/0283303 A1, Sep. 16, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. A61L 27/54 (2006.01); A01N 25/34 (2006.01); A61B 17/54 (2006.01); A61B 17/58 (2006.01); A61B 17/80 (2006.01); A61B 17/84 (2006.01); A61B 17/86 (2006.01); A61K 33/24 (2019.01); A61K 33/242 (2019.01); A61K 33/243 (2019.01); A61K 33/30 (2006.01); A61K 33/38 (2006.01); A61L 27/18 (2006.01); A61L 27/30 (2006.01); A61L 27/58 (2006.01); A61L 29/10 (2006.01); A61L 29/16 (2006.01); A61L 31/06 (2006.01); A61L 31/08 (2006.01); A61L 31/14 (2006.01); A61L 31/16 (2006.01); C08L 67/04 (2006.01)
CPC A61L 27/18 (2013.01) [A01N 25/34 (2013.01); A61K 33/24 (2013.01); A61K 33/242 (2019.01); A61K 33/243 (2019.01); A61K 33/30 (2013.01); A61K 33/38 (2013.01); A61L 27/306 (2013.01); A61L 27/54 (2013.01); A61L 27/58 (2013.01); A61L 29/106 (2013.01); A61L 29/16 (2013.01); A61L 31/06 (2013.01); A61L 31/088 (2013.01); A61L 31/148 (2013.01); A61L 31/16 (2013.01); C08L 67/04 (2013.01); A61L 2300/102 (2013.01); A61L 2300/104 (2013.01); A61L 2300/404 (2013.01); A61L 2300/602 (2013.01); A61L 2300/604 (2013.01); A61L 2300/606 (2013.01); A61L 2400/18 (2013.01); A61L 2420/06 (2013.01)] 17 Claims
OG exemplary drawing
 
1. An implantable device comprising:
a device body formed of a substrate;
a coating on the device body, the coating comprising a mixture of an anodic metal and a cathodic metal, wherein the mixture of the anodic metal and the cathodic metal comprises a plurality of microregions or microdomains of anodic metal in a matrix of cathodic metal or a plurality of microregions or microdomains of cathodic metal in a matrix of anodic metal, the microregions or microdomains forming interconnected veins of anodic metal through a thickness of the coating, or interconnected veins of cathodic metal through the thickness of the coating, so that the anodic metal is galvanically released as antimicrobial ions when the device body is exposed to a bodily fluid.