US 11,925,641 B2
Pyrazole pyrimidine derivative and uses thereof
Yinon Ben-Neriah, Mevasseret Zion (IL); Guy Brachya, Jerusalem (IL); Ido Burstain, Moshav Sde-Yaakov (IL); Waleed Minzel, Kafr-Kanna (IL); Irit Snir-Alkalay, Mevasseret Zion (IL); Joseph P. Vacca, Telford, PA (US); and Dansu Li, Warrington, PA (US)
Assigned to Yissum Research Development Company of the Hebrew University of Jerusalem Ltd, Jerusalem (IL)
Filed by Yissum Research Development Company of the Hebrew University of Jerusalem Ltd., Jerusalem (IL)
Filed on Mar. 29, 2021, as Appl. No. 17/215,959.
Application 17/215,959 is a continuation of application No. 16/538,550, filed on Aug. 12, 2019, granted, now 10,960,003.
Application 16/538,550 is a continuation of application No. 15/748,536, granted, now 10,376,511, issued on Aug. 13, 2019, previously published as PCT/IL2016/050852, filed on Aug. 4, 2016.
Claims priority of provisional application 62/268,750, filed on Dec. 17, 2015.
Claims priority of provisional application 62/200,846, filed on Aug. 4, 2015.
Prior Publication US 2021/0251992 A1, Aug. 19, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 31/506 (2006.01); A61P 35/02 (2006.01); C07D 403/04 (2006.01); C07D 405/14 (2006.01); C07D 413/14 (2006.01)
CPC A61K 31/506 (2013.01) [A61P 35/02 (2018.01); C07D 403/04 (2013.01); C07D 405/14 (2013.01); C07D 413/14 (2013.01)] 19 Claims
 
1. A compound of formula (I):

OG Complex Work Unit Chemistry
or a stereoisomer or pharmaceutically acceptable salt thereof; wherein:
R1 and R2 are each independently H; or straight or branched C1-C8 alkyl, straight or branched C1-C5 alkoxy, or straight or branched C1-C5 acyl, each optionally substituted by at least one of halide or hydroxyl; or
R3 and R4 are each independently H; or straight or branched C1-C8 alkyl, each optionally substituted by at least one of halide, hydroxyl, or C1-C5 alkoxy R5 and R8 are each independently H or halide; or straight or branched C1-C8 alkyl, straight or branched C2-C8 alkenyl, or straight or branched C2-C8 alkynyl each optionally substituted by at least one halide;
R6 is straight or branched C1-C8 alkyl, straight or branched C2-C8 alkenyl, straight or branched C2-C8 alkynyl, C5-C10 cycloalkyl, or saturated or unsaturated 4-6 membered heterocyclyl, each optionally substituted by at least one of straight or branched C1-C8 alkyl, C3-C7 cycloalkyl, 4-6 membered heterocyclyl, halide, hydroxyl, or C1-C5 haloalkyl; and
R7 is straight or branched C1-C8 alkyl, straight or branched C2-C8 alkenyl, straight or branched C2-C8 alkynyl, each substituted by at least one C3-C7 cycloalkyl, 4-6 membered heterocyclyl, halide, hydroxyl, or C1-C5 haloalkyl.