US 11,925,547 B2
Prosthesis for in vivo insertion, coated with cross-linked polyphosphorylcholine
Tae Hyun Choi, Seoul (KR); Yan Lee, Seoul (KR); Ji Ung Park, Seoul (KR); Ji Yeon Ham, Changwon-si (KR); Hee Jin Kim, Pyeongtaek-si (KR); Suk Wha Kim, Seoul (KR); and Hye Jeong Min, Seoul (KR)
Assigned to SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION, Seoul (KR)
Filed by SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION, Seoul (KR); and BS RESEARCH CO. LTD., Seoul (KR)
Filed on Aug. 25, 2021, as Appl. No. 17/412,124.
Application 17/412,124 is a division of application No. 15/304,780, granted, now 11,129,706, previously published as PCT/KR2015/003879, filed on Apr. 17, 2015.
Claims priority of application No. 10-2014-0045713 (KR), filed on Apr. 17, 2014.
Prior Publication US 2021/0378814 A1, Dec. 9, 2021
Int. Cl. A61F 2/12 (2006.01); A61F 2/00 (2006.01); A61L 27/28 (2006.01); A61L 27/32 (2006.01); A61L 27/34 (2006.01); B05D 1/02 (2006.01); C08F 2/48 (2006.01)
CPC A61F 2/12 (2013.01) [A61F 2/0059 (2013.01); A61F 2/0063 (2013.01); A61L 27/28 (2013.01); A61L 27/32 (2013.01); A61L 27/34 (2013.01); B05D 1/02 (2013.01); A61F 2002/0086 (2013.01); A61F 2002/009 (2013.01); A61L 2300/216 (2013.01); A61L 2400/18 (2013.01); A61L 2430/04 (2013.01); C08F 2/48 (2013.01)] 7 Claims
OG exemplary drawing
 
1. An in-vivo implantable prosthesis coated with a crosslinked polymeric surface by crosslinking a coating composition comprising a photoinitiator, a crosslinking agent, and a phosphorylcholine monomer having an acrylate group,
wherein the photoinitiator is selected from the group consisting of benzophenone, benzoyl peroxide, and 2,2-dimethoxy-2-phenylacetophenone;
wherein the coating composition comprises the photoinitiator in an amount ranging from 0.01 to 0.2 mol % and the crosslinking agent in an amount ranging from 0.01 to 2.0 mol %, with respect to the phosphorylcholine monomer;
wherein crosslinked polyphosphorylcholine formed by crosslinking the coating composition is covalently bonded with an external surface of the in-vivo implantable prosthesis; and
wherein the external surface material of the in-vivo implantable prosthesis comprises polydimethylsiloxane having functional groups which provide radicals that react with a terminal C═C bond of the acrylate group of phosphorylcholine via the photoinitiator to form covalent bonds.