CPC A61F 2/12 (2013.01) [A61F 2/0059 (2013.01); A61F 2/0063 (2013.01); A61L 27/28 (2013.01); A61L 27/32 (2013.01); A61L 27/34 (2013.01); B05D 1/02 (2013.01); A61F 2002/0086 (2013.01); A61F 2002/009 (2013.01); A61L 2300/216 (2013.01); A61L 2400/18 (2013.01); A61L 2430/04 (2013.01); C08F 2/48 (2013.01)] | 7 Claims |
1. An in-vivo implantable prosthesis coated with a crosslinked polymeric surface by crosslinking a coating composition comprising a photoinitiator, a crosslinking agent, and a phosphorylcholine monomer having an acrylate group,
wherein the photoinitiator is selected from the group consisting of benzophenone, benzoyl peroxide, and 2,2-dimethoxy-2-phenylacetophenone;
wherein the coating composition comprises the photoinitiator in an amount ranging from 0.01 to 0.2 mol % and the crosslinking agent in an amount ranging from 0.01 to 2.0 mol %, with respect to the phosphorylcholine monomer;
wherein crosslinked polyphosphorylcholine formed by crosslinking the coating composition is covalently bonded with an external surface of the in-vivo implantable prosthesis; and
wherein the external surface material of the in-vivo implantable prosthesis comprises polydimethylsiloxane having functional groups which provide radicals that react with a terminal C═C bond of the acrylate group of phosphorylcholine via the photoinitiator to form covalent bonds.
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