US 11,925,546 B2
Soft tissue repair and methods for preparing same
Michael Locarno, Kinnelon, NJ (US); Bryan Choi, San Marcos, CA (US); and Manh-Dan Ngo, Matawan, NJ (US)
Assigned to Musculoskeletal Transplant Foundation, Edison, NJ (US)
Filed by Musculoskeletal Transplant Foundation, Edison, NJ (US)
Filed on Dec. 3, 2020, as Appl. No. 17/111,147.
Application 17/111,147 is a division of application No. 16/244,190, filed on Jan. 10, 2019, granted, now 10,881,501.
Application 16/244,190 is a division of application No. 15/621,602, filed on Jun. 13, 2017, granted, now 10,238,485, issued on Mar. 26, 2019.
Application 15/621,602 is a continuation of application No. 14/208,025, filed on Mar. 13, 2014, abandoned.
Claims priority of provisional application 61/783,237, filed on Mar. 14, 2013.
Prior Publication US 2021/0085448 A1, Mar. 25, 2021
Int. Cl. A61F 2/10 (2006.01); A61K 35/36 (2015.01); A61L 27/36 (2006.01); A61L 27/38 (2006.01); A61L 27/60 (2006.01); C12N 5/071 (2010.01)
CPC A61F 2/105 (2013.01) [A61K 35/36 (2013.01); A61L 27/362 (2013.01); A61L 27/3683 (2013.01); A61L 27/38 (2013.01); A61L 27/60 (2013.01); C12N 5/0698 (2013.01)] 16 Claims
 
6. An allograft hybrid bilayer tissue form for use in surgical procedures comprising a dermal side and an adipose side, wherein said allograft hybrid layer tissue form is derived from a donor skin tissue which comprised (a) an epidermis; (b) a dermis underlying the epidermis, the dermis including a papillary dermis adjacent the epidermis, a reticular dermis distal to the epidermis, and a papillary-reticular dermis interface between the papillary dermis and reticular dermis; and (c) at least a portion of a hypodermis adipose tissue underlying the reticular dermis of (b) the dermis, wherein the dermal side of said tissue form is formed by a portion of the reticular dermis and the adipose side of said tissue form is formed by said at least a portion of hypodermis, and wherein the allograft hybrid bilayer tissue form essentially lacks an epidermis, a papillary dermis, papillary-reticular dermis interface, and a portion of the reticular dermis attached to the papillary- reticular dermis interface.