US 11,925,531 B2
Magnetic dressing and preparation method and use thereof
Na Liu, Shanghai (CN); Ziheng Chen, Shanghai (CN); Huiyu Yuan, Shanghai (CN); Dan Zhang, Shanghai (CN); Kewei Zhang, Shanghai (CN); Tao Yue, Shanghai (CN); Yuanyuan Liu, Shanghai (CN); and Yan Peng, Shanghai (CN)
Assigned to Shanghai University, Shanghai (CN)
Filed by SHANGHAI UNIVERSITY, Shanghai (CN)
Filed on Sep. 13, 2022, as Appl. No. 17/943,356.
Claims priority of application No. 202111079086.8 (CN), filed on Sep. 15, 2021.
Prior Publication US 2023/0081314 A1, Mar. 16, 2023
Int. Cl. A61F 13/00 (2006.01); A61F 13/02 (2006.01); A61F 13/84 (2006.01); A61L 15/18 (2006.01); A61L 15/20 (2006.01); A61L 15/44 (2006.01); A61L 15/62 (2006.01)
CPC A61F 13/00029 (2013.01) [A61F 13/00017 (2013.01); A61F 13/00034 (2013.01); A61F 13/0286 (2013.01); A61L 15/18 (2013.01); A61L 15/20 (2013.01); A61L 15/44 (2013.01); A61L 15/62 (2013.01); A61F 2013/8479 (2013.01); A61L 2300/41 (2013.01)] 19 Claims
 
1. A magnetic dressing configured for targeted therapy, comprising: a magnetic layer, a drug-loading layer, and a protective layer that are stacked in sequence, wherein the magnetic layer comprises polyvinyl alcohol, gluten, and iron particles; a swallowed magnetic dressing is controlled by an external magnetic field, and the magnetic dressing is moved to a pathological position by changing a direction of the external magnetic field, thereby achieving a fixed-point release of a drug; the magnetic dressing appears a ring shape under an action of the external magnetic field, and the ring shape makes the magnetic dressing enter the human body by swallowing; after removing the external magnetic field, the magnetic dressing changes from the ring shape to a sheet shape, completing attachment of an entire lesion surface to complete a treatment by conducting autonomous drug release; the magnetic layer as an inner side and the drug-loading layer as an outer side are bent on a cylindrical surface, and magnetization is conducted; and the magnetization enables the magnetic layer to have a specific magnetization curve, enabling swallowing and delivery of the dressing, wherein raw materials of the magnetic dressing are biodegradable and after the magnetic dressing is removed from the affected parts a permanent magnet is removed to terminate the treatment, and wherein the magnetic dressing is naturally degraded in the human body.