	US 11,925,463 B2
	Method and multisensory device for non-invasive blood glucose level monitoring
Ramil Faritovich Musin, Moscow (RU)
Assigned to LCM Biosensor Technologies, Inc., East Setauket, NY (US)
Appl. No. 16/303,371
Filed by “INTERCELLULAR SUBSTANCE TECHNOLOGIES LABORATORY R&D INTERCELL” LIMITED LIABILITY COMPANY (“R&D INTERCELL” LLC), Moscow (RU)
PCT Filed Aug. 19, 2016, PCT No. PCT/RU2016/000561 § 371(c)(1), (2) Date Nov. 20, 2018, PCT Pub. No. WO2017/204677, PCT Pub. Date Nov. 30, 2017.
Claims priority of application No. RU2016119799 (RU), filed on May 23, 2016.
Prior Publication US 2020/0060584 A1, Feb. 27, 2020
Int. Cl. A61B 5/145 (2006.01); A61B 5/00 (2006.01); A61B 5/01 (2006.01); A61B 5/0205 (2006.01); A61B 5/0533 (2021.01)

CPC A61B 5/14532 (2013.01) [A61B 5/0006 (2013.01); A61B 5/015 (2013.01); A61B 5/02055 (2013.01); A61B 5/0533 (2013.01); A61B 5/4866 (2013.01); A61B 5/6831 (2013.01); A61B 2562/0271 (2013.01); A61B 2562/029 (2013.01); A61B 2562/063 (2013.01)]

60 Claims

1. A method for monitoring blood glucose levels, the method comprising:

applying at least one heat and waterproof applicator to a skin surface with a dosed pressure, forming a closed system in a local area of living tissue under the applicator;

exerting an external physical effect on the local area of the tissue under the applicator, including the dosed pressure;

measuring temporal dynamics of physiological parameters in the local area of the living tissue under the applicator, including at least the temporal dynamics of:

osmotic pressure of an intercellular substance and/or an amount of water in an intercellular space of the tissue under the applicator;

temperature of a dermis under the applicator via radio thermometry or heat flow through a skin area under the applicator via a heat detector; and

elastic pressure of the tissue under the applicator,

measuring values of environmental climatic parameters before beginning the measurement of the temporal dynamics of the physiological parameters, including at least:

room temperature and relative humidity in a measurement room; and

atmosphere pressure,

measuring an external environment temperature or external heat flow through an enclosing structure between the measurement room and an external environment;

calculating a value of enthalpy, H, in a layer of the tissue under the applicator accounting for an influence of the climatic parameters, according to the formula:

H=H₀(T_skin, P_sensor)xθ(T_room, T_ext, RH_room, P_atm), where

T_skinis the temperature of the dermis,

P_sensoris the dosed pressure of the applicator on the skin surface,

T_roomis the room temperature,

T_extis an ambient air temperature behind the enclosing structure,

RH_roomis the relative humidity in the measurement room, and

P_atmis the atmospheric pressure; and

calculating changes in blood glucose level based on a thermodynamics equation that connects the enthalpy with thermodynamic variables or variables of a thermodynamic state.