US 12,247,989 B2
Multi-channel device for calculating coagulation characteristics of a patient's liquid test sample and methods of use related thereto
Aaron Kauffmann, Elkhart, IN (US)
Assigned to Siemens Healthcare Diagnostics Inc., Tarrytown, NY (US)
Appl. No. 17/279,890
Filed by Siemens Healthcare Diagnostics Inc., Tarrytown, NY (US)
PCT Filed Sep. 23, 2019, PCT No. PCT/US2019/052366
§ 371(c)(1), (2) Date Mar. 25, 2021,
PCT Pub. No. WO2020/068628, PCT Pub. Date Apr. 2, 2020.
Claims priority of provisional application 62/737,440, filed on Sep. 27, 2018.
Prior Publication US 2022/0034914 A1, Feb. 3, 2022
Int. Cl. G01N 33/86 (2006.01); B01L 3/00 (2006.01); G01N 21/03 (2006.01); G01N 21/27 (2006.01); G01N 21/75 (2006.01)
CPC G01N 33/86 (2013.01) [B01L 3/502 (2013.01); G01N 21/03 (2013.01); G01N 21/272 (2013.01); G01N 21/75 (2013.01); B01L 2200/025 (2013.01); B01L 2200/026 (2013.01); B01L 2200/0684 (2013.01); B01L 2200/16 (2013.01); B01L 2300/12 (2013.01); G01N 2021/0325 (2013.01); G01N 2021/0346 (2013.01)] 19 Claims
OG exemplary drawing
 
1. A coagulation device for the conductance of coagulation assays on a patient's liquid test sample to determine a plurality of coagulation characteristics associated with intrinsic and extrinsic pathways of coagulation, the coagulation device comprising:
a top section, the top section comprising at least one side, a top portion, a bottom portion, and a sample receptacle;
a bottom section, the bottom section comprising at least one side, a top portion, and a bottom portion;
a center section, the center section comprising at least one side, a top portion, and a bottom portion, the center section being disposed between the top section and the bottom section, the center section further comprising at least two channels, wherein each of the at least two channels comprises an opening in fluid communication with the sample receptacle for receiving a patient's liquid test sample, further wherein each of the at least two channels is open to the top portion of the bottom section and each of the at least two channels comprises a sample window containing at least one coagulation assay reagent for conducting at least one coagulation assay in each of the at least two channels, the center section further comprising at least one spacer that completely separates each of the at least two channels from one another such that the at least two channels never cross, thereby preventing cross-contamination between the at least two channels; and
wherein the at least one coagulation assay is measured by optical interrogation at a specific wavelength by an optical source, wherein the specific wavelength is in a range of from about 750 nanometers to about 1,000 nanometers.