US 12,247,978 B2
Compositions and methods for detection and treatment of coronavirus infection
John Altin, Flagstaff, AZ (US); and Jason Ladner, Flagstaff, AZ (US)
Assigned to Arizona Board of Regents on behalf of Northern Arizona University, Flagstaff, AZ (US)
Filed by THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE, Phoenix, AZ (US); and ARIZONA BOARD OF REGENTS ON BEHALF OF NORTHERN ARIZONA UNIVERSITY, Flagstaff, AZ (US)
Filed on Aug. 5, 2021, as Appl. No. 17/395,330.
Claims priority of provisional application 63/061,344, filed on Aug. 5, 2020.
Prior Publication US 2022/0042992 A1, Feb. 10, 2022
Int. Cl. G01N 33/569 (2006.01); A61K 31/18 (2006.01); A61K 31/22 (2006.01); A61K 31/40 (2006.01); A61K 31/7052 (2006.01); A61K 39/215 (2006.01); A61P 11/00 (2006.01); C12N 7/00 (2006.01); G01N 33/68 (2006.01)
CPC G01N 33/56983 (2013.01) [A61K 31/18 (2013.01); A61K 31/22 (2013.01); A61K 31/40 (2013.01); A61K 31/7052 (2013.01); A61K 39/215 (2013.01); A61P 11/00 (2018.01); C12N 7/00 (2013.01); G01N 33/6884 (2013.01); C12N 2770/20034 (2013.01); G01N 2333/165 (2013.01); G01N 2800/12 (2013.01); G01N 2800/245 (2013.01); G01N 2800/50 (2013.01)] 5 Claims
OG exemplary drawing
 
1. A method of detecting in a sample a presence of an antibody that binds to a spike protein or a nucleocapsid protein of a severe acute respiratory syndrome-associated coronavirus (SARS-COV), the method comprising:
providing a biological sample from a subject suspected to be infected with a SARS-COV;
contacting the biological sample with a peptide consisting of the amino acid sequence: EDLLFN (SEQ ID NO: 422); and
detecting antigen-antibody complexes formed.