US 12,247,919 B2
Methods and systems utilizing optically-powered sensing integrated circuit(s) with optical information transfer
Kenneth L. Shepard, Ossining, NY (US); and Girish Ramakrishnan, New York, NY (US)
Assigned to THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
Filed by THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, New York, NY (US)
Filed on Jun. 28, 2021, as Appl. No. 17/360,667.
Application 17/360,667 is a division of application No. 16/041,373, filed on Jul. 20, 2018, granted, now 11,112,360.
Application 16/041,373 is a continuation of application No. PCT/US2017/014569, filed on Jan. 23, 2017.
Claims priority of provisional application 62/281,566, filed on Jan. 21, 2016.
Prior Publication US 2021/0404963 A1, Dec. 30, 2021
Int. Cl. G01N 21/64 (2006.01); A61B 5/00 (2006.01); G02F 1/025 (2006.01); H01L 31/0232 (2014.01); G02F 1/015 (2006.01)
CPC G01N 21/6428 (2013.01) [A61B 5/0031 (2013.01); G02F 1/025 (2013.01); H01L 31/02327 (2013.01); A61B 2560/0214 (2013.01); G02F 1/0157 (2021.01)] 20 Claims
OG exemplary drawing
 
1. A method for performing non-destructive sensing of a cell or a tissue, the method comprising:
implanting an integrated circuit into the cell or the tissue, wherein the integrated circuit comprises:
an energy harvestor configured to collect light from an optical source,
a sensor, coupled to the energy harvestor to be powered thereby, and configured to measure one or more signals associated with the cell or the tissue, and
at least one electro-optical modulator comprising a plurality of fluorescent materials and configured to receive the one or more signals and generate one or more optical signals;
receiving, by the integrated circuit, light transmitted by the optical source;
modulating the one or more signals with the transmitted light, by the optical modulator, to generate the one or more optical signals; and
transmitting the one or more optical signals, by the optical modulator.