US 12,247,910 B2
High resolution fluorescence imaging device and method for manufacturing the same
Il-Joo Cho, Seoul (KR); Nakwon Choi, Seoul (KR); and Hyogeun Shin, Seoul (KR)
Assigned to Korea Institute of Science and Technology, Seoul (KR)
Filed by KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY, Seoul (KR)
Filed on Oct. 7, 2022, as Appl. No. 17/962,066.
Prior Publication US 2023/0110294 A1, Apr. 13, 2023
Int. Cl. G01N 15/1434 (2024.01); F21V 8/00 (2006.01); G01N 15/14 (2024.01); G02B 1/04 (2006.01)
CPC G01N 15/1436 (2013.01) [G01N 15/1484 (2013.01); G02B 1/045 (2013.01); G02B 6/0068 (2013.01)] 10 Claims
OG exemplary drawing
 
1. A high resolution fluorescence imaging device, comprising:
a light guide plate having a fluid channel which allows a solution containing a fluorescent sample to pass;
a light source disposed on a side of the light guide plate to irradiate light inward the light guide plate;
an image sensor disposed under the light guide plate; and
a thin film interposed between the light guide plate and the image sensor, wherein the thin film has a first surface having a plurality of pillars and a second surface, the pillars separate the light guide plate and the image sensor apart from each other, and the second surface is bonded to the light guide plate,
wherein the thin film and the plurality of pillars are made of a material having a refractive index that is higher than a refractive index of air and lower than a refractive index of the light quide plate, and an output light from the light source is totally internally reflected in the light guide plate and the thin film.