US 12,247,906 B2
Particle emission tomography
Harrison H. Barrett, Tucson, AZ (US); Yijun Ding, Tucson, AZ (US); Luca Caucci, Tucson, AZ (US); and John William Hoppin, Boston, MA (US)
Assigned to Arizona Board of Regents on behalf of the University of Arizona, Tucson, AZ (US); and inviCro, LLC, Boston, MA (US)
Filed by Arizona Board of Regents on Behalf of the University of Arizona, Tucson, AZ (US); and inviCro, LLC, Boston, MA (US)
Filed on Oct. 20, 2021, as Appl. No. 17/506,396.
Application 17/506,396 is a continuation of application No. 16/653,922, filed on Oct. 15, 2019, granted, now 11,249,000.
Application 16/653,922 is a continuation of application No. 15/526,514, granted, now 10,444,136, issued on Oct. 15, 2019, previously published as PCT/US2015/060198, filed on Nov. 11, 2015.
Claims priority of provisional application 62/199,904, filed on Jul. 31, 2015.
Claims priority of provisional application 62/078,562, filed on Nov. 12, 2014.
Prior Publication US 2022/0187181 A1, Jun. 16, 2022
Int. Cl. G01N 15/02 (2024.01); A61B 6/00 (2006.01); A61B 6/03 (2006.01); A61B 6/42 (2024.01); G01B 7/004 (2006.01); G01N 15/0227 (2024.01); G01T 1/29 (2006.01)
CPC G01N 15/0227 (2013.01) [A61B 6/037 (2013.01); A61B 6/4241 (2013.01); A61B 6/4258 (2013.01); A61B 6/5205 (2013.01); G01B 7/004 (2013.01); G01N 15/02 (2013.01); G01T 1/2942 (2013.01)] 13 Claims
OG exemplary drawing
 
1. A device for reconstructing a 3D distribution of a source of particles from within a tissue sample, wherein the particles comprise beta particles, alpha particles, positrons, or conversion electrons, the device comprising:
a particle-processing detector for detecting particles;
a processor positioned in data communication with the particle-processing detector, wherein the processor is configured for:
determining attributes of the particle; wherein the attributes include:
(i) a particle interaction time; and
(ii) energy of the particle upon interacting with the detector;
and wherein the attributes additionally include at least two of:
(iii) a two dimensional position corresponding to an interaction point where the particle interacts with the particle-processing detector;
(iv) an energy that is deposited in the particle-processing detector by the particle; or
(v) a direction of travel of the particle; and
storing the attributes of the particle;
thereby generating attributes for each of a plurality of particles from the source; and
reconstructing the 3D distribution of the source of particles using at least a portion of the attributes for each of the plurality of particles.