US 12,247,320 B2
Multivalent glycopeptides that tightly bind to carbohydrate-binding monoclonal antibody family PGT128
Isaac J. Krauss, Needham Heights, MA (US); Satoru Horiya, Somerville, MA (US); and Jennifer Bailey, Waltham, MA (US)
Assigned to Brandeis University, Waltham, MA (US)
Appl. No. 17/288,414
Filed by BRANDEIS UNIVERSITY, Waltham, MA (US)
PCT Filed Oct. 24, 2019, PCT No. PCT/US2019/057921
§ 371(c)(1), (2) Date Apr. 23, 2021,
PCT Pub. No. WO2020/086885, PCT Pub. Date Apr. 30, 2020.
Claims priority of provisional application 62/879,372, filed on Jul. 26, 2019.
Claims priority of provisional application 62/750,217, filed on Oct. 24, 2018.
Prior Publication US 2022/0090055 A1, Mar. 24, 2022
Int. Cl. C40B 40/10 (2006.01); C07K 19/00 (2006.01); C12N 15/10 (2006.01)
CPC C40B 40/10 (2013.01) [C07K 19/00 (2013.01); C12N 15/1058 (2013.01); C12N 15/1062 (2013.01)] 18 Claims
OG exemplary drawing
 
1. A glycopeptide comprising one or more modified amino acid residues having a sidechain comprising an oligosaccharide,
wherein the glycopeptide comprises IGDIR (SEQ ID NO: 1) or IGDIRxA (SEQ ID NO: 2),
wherein the modified amino acid comprises homopropargylglycine, p-azido-phenylalanine, p-ethynyl-phenylalanine, or L-allyl glycine,
wherein the glycopeptide binds specifically to carbohydrate-binding monoclonal antibody PGT128 with an affinity of less than 100 nM.