US 12,247,073 B2
Anti-CD33 antibodies and methods of use thereof
Patricia Culp, Oakland, CA (US); Helen Lam, Union City, CA (US); Wei-Hsien Ho, Belmont, CA (US); Leonard G. Presta, Palo Alto, CA (US); and Arnon Rosenthal, Woodside, CA (US)
Assigned to ALECTOR LLC, South San Francisco, CA (US)
Appl. No. 17/272,083
Filed by Alector LLC, South San Francisco, CA (US)
PCT Filed Aug. 30, 2019, PCT No. PCT/US2019/048994
§ 371(c)(1), (2) Date Feb. 26, 2021,
PCT Pub. No. WO2020/047374, PCT Pub. Date Mar. 5, 2020.
Claims priority of provisional application 62/726,053, filed on Aug. 31, 2018.
Prior Publication US 2021/0317208 A1, Oct. 14, 2021
Int. Cl. C07K 16/28 (2006.01)
CPC C07K 16/2803 (2013.01) [C07K 2317/24 (2013.01); C07K 2317/31 (2013.01); C07K 2317/52 (2013.01); C07K 2317/92 (2013.01)] 84 Claims
 
1. An isolated antibody that binds to CD33, wherein the antibody comprises a heavy chain variable region comprising an HVR-H1, HVR-H2, and HVR-H3 and a light chain variable region comprising an HVR-L1, HVR-L2, and HVR-L3, wherein
the HVR-H1 comprises the amino acid sequence of SEQ ID NO: 23, the HVR-H2 comprises the amino acid sequence of SEQ ID NO: 33, the HVR-H3 comprises the amino acid sequence of SEQ ID NO: 39, the HVR-L1 comprises the amino acid sequence of SEQ ID NO: 47, the HVR-L2 comprises the amino acid sequence of SEQ ID NO: 53, and the HVR-L3 comprises the amino acid sequence of SEQ ID NO: 60;
the HVR-H1 comprises the amino acid sequence of SEQ ID NO: 23, the HVR-H2 comprises the amino acid sequence of SEQ ID NO: 33, the HVR-H3 comprises the amino acid sequence of SEQ ID NO: 39, the HVR-L1 comprises the amino acid sequence of SEQ ID NO: 47, the HVR-L2 comprises the amino acid sequence of SEQ ID NO: 53, and the HVR-L3 comprises the amino acid sequence of SEQ ID NO: 62;
the HVR-H1 comprises the amino acid sequence of SEQ ID NO: 30, the HVR-H2 comprises the amino acid sequence of SEQ ID NO: 33, the HVR-H3 comprises the amino acid sequence of SEQ ID NO: 39, the HVR-L1 comprises the amino acid sequence of SEQ ID NO: 47, the HVR-L2 comprises the amino acid sequence of SEQ ID NO: 53, and the HVR-L3 comprises the amino acid sequence of SEQ ID NO: 61; or
the HVR-H1 comprises the amino acid sequence of SEQ ID NO: 23, the HVR-H2 comprises the amino acid sequence of SEQ ID NO: 33, the HVR-H3 comprises the amino acid sequence of SEQ ID NO: 39, the HVR-L1 comprises the amino acid sequence of SEQ ID NO: 47, the HVR-L2 comprises the amino acid sequence of SEQ ID NO: 53, and the HVR-L3 comprises the amino acid sequence of SEQ ID NO: 61.