	US 12,247,066 B2
	Monoclonal antibody 14F5F6 or fragment thereof, that specifically recognizes herpes simplex virus 1 and 2
Alexis Kalergis Parra, Santiago (CL); Susan Bueno Ramírez, Santiago (CL); and Pablo Gonzalez Muñoz, Santiago (CL)
Assigned to Pontificia Universídad Católica de Chile, Santiago (CL); and Fundacion Copec Universidad Católica, Santiago (CL)
Appl. No. 17/272,027
Filed by PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE, Santiago (CL); and FUNDACION COPEC UNIVERSIDAD CATÓLICA, Santiago (CL)
PCT Filed Aug. 28, 2018, PCT No. PCT/CL2018/050074 § 371(c)(1), (2) Date Feb. 26, 2021, PCT Pub. No. WO2020/041910, PCT Pub. Date Mar. 5, 2020.
Prior Publication US 2021/0347856 A1, Nov. 11, 2021
Int. Cl. C07K 16/08 (2006.01); G01N 33/569 (2006.01); G01N 33/577 (2006.01)

CPC C07K 16/087 (2013.01) [G01N 33/56994 (2013.01); G01N 33/577 (2013.01); C07K 2317/24 (2013.01); C07K 2317/565 (2013.01); G01N 2333/035 (2013.01); G01N 2800/26 (2013.01)]

14 Claims

1. A monoclonal antibody or an antigen-binding fragment thereof that specifically recognizes herpes simplex virus type 1 (HSV-1) and herpes simplex virus type 2 (HSV-2),

wherein said antibody or the antigen-binding fragment thereof has a variable region of a heavy chain in which CDR1, CDR2, and CDR3 have amino acid sequences defined in SEQ ID No:3, SEQ ID No:4, and SEQ ID No: 5, respectively, and at the same time has a variable region of a light chain in which CDR1, CDR2 and CDR3 have amino acid sequences defined in SEQ ID No:6, SEQ ID No:7 and SEQ ID No:8, respectively.