US 12,247,058 B2
Nucleic acids encoding modified FGF-21 polypeptides, vectors and cells containing, and use thereof
Paul E. Morin, Pennington, NJ (US); Daniel Cohen, New York, NY (US); Ranjan Mukherjee, Churchville, PA (US); Timothy P. Reilly, New Hope, PA (US); Rose C. Christian, Hopewell, NJ (US); Dasa Lipovsek, Pepperell, MA (US); Ray Camphausen, Wayland, MA (US); and John Krupinski, Flemington, NJ (US)
Assigned to BRISTOL-MYERS SQUIBB COMPANY, Princeton, NJ (US)
Filed by BRISTOL-MYERS SQUIBB COMPANY, Princeton, NJ (US)
Filed on Dec. 20, 2021, as Appl. No. 17/555,633.
Application 17/555,633 is a division of application No. 16/455,990, filed on Jun. 28, 2019, granted, now 11,248,031.
Application 16/455,990 is a division of application No. 15/979,881, filed on May 15, 2018, granted, now 10,377,806, issued on Aug. 13, 2019.
Application 15/979,881 is a division of application No. 15/460,917, filed on Mar. 16, 2017, granted, now 10,189,883, issued on Jan. 29, 2019.
Application 15/460,917 is a division of application No. 15/215,329, filed on Jul. 20, 2016, granted, now 9,631,004, issued on Apr. 25, 2017.
Application 15/215,329 is a continuation of application No. 14/921,796, filed on Oct. 23, 2015, granted, now 9,434,778.
Claims priority of provisional application 62/141,383, filed on Apr. 1, 2015.
Claims priority of provisional application 62/141,337, filed on Apr. 1, 2015.
Claims priority of provisional application 62/068,526, filed on Oct. 24, 2014.
Claims priority of provisional application 62/068,534, filed on Oct. 24, 2014.
Claims priority of provisional application 62/068,296, filed on Oct. 24, 2014.
Claims priority of provisional application 62/068,514, filed on Oct. 24, 2014.
Claims priority of provisional application 62/068,523, filed on Oct. 24, 2014.
Prior Publication US 2022/0185856 A1, Jun. 16, 2022
Int. Cl. C12N 15/12 (2006.01); A61K 38/18 (2006.01); A61K 45/06 (2006.01); A61K 47/60 (2017.01); A61K 47/64 (2017.01); C07K 14/50 (2006.01); C12N 5/10 (2006.01); A61K 38/00 (2006.01)
CPC C07K 14/50 (2013.01) [A61K 38/1825 (2013.01); A61K 45/06 (2013.01); A61K 47/60 (2017.08); A61K 47/64 (2017.08); A61K 38/00 (2013.01); C07K 2319/00 (2013.01); C07K 2319/30 (2013.01)] 21 Claims
 
1. An isolated nucleic acid encoding a modified FGF-21 polypeptide having at least 98% amino acid sequence identity to SEQ ID NO: 102.