US 12,247,056 B2
Multi-epitope vaccine for the treatment of Alzheimer's disease
Robin Barbour, Walnut Creek, CA (US); Gene Kinney, Boca Raton, FL (US); Wagner Zago, San Carlos, CA (US); and Tarlochan S. Nijjar, Orinda, CA (US)
Assigned to Othair Prothena Limited, Dublin (IE)
Filed by OTHAIR PROTHENA LIMITED, Dublin (IE)
Filed on Mar. 4, 2024, as Appl. No. 18/594,435.
Application 18/594,435 is a division of application No. 18/328,528, filed on Jun. 2, 2023, granted, now 11,945,849.
Application 18/328,528 is a division of application No. 17/925,813, abandoned, previously published as PCT/US2021/033222, filed on May 19, 2021.
Claims priority of provisional application 63/140,917, filed on Jan. 24, 2021.
Claims priority of provisional application 63/062,903, filed on Aug. 7, 2020.
Claims priority of provisional application 63/027,150, filed on May 19, 2020.
Prior Publication US 2024/0343769 A1, Oct. 17, 2024
Int. Cl. A61K 39/00 (2006.01); A61K 38/00 (2006.01); A61K 39/39 (2006.01); A61P 25/28 (2006.01); A61P 37/04 (2006.01); C07K 14/47 (2006.01)
CPC C07K 14/4711 (2013.01) [A61K 39/0007 (2013.01); A61K 39/39 (2013.01); A61P 25/28 (2018.01); A61P 37/04 (2018.01); A61K 2039/53 (2013.01); A61K 2039/545 (2013.01); A61K 2039/55516 (2013.01); A61K 2039/55544 (2013.01); A61K 2039/55555 (2013.01); A61K 2039/55572 (2013.01); A61K 2039/55577 (2013.01); A61K 2039/575 (2013.01); A61K 2039/6037 (2013.01); C07K 2319/00 (2013.01)] 26 Claims
 
1. A polypeptide comprising a first peptide comprising amino acid sequence EFR and comprising sequence 3-10 amino acids from residues 1-10 of SEQ ID NO:01 linked to a second peptide comprising amino acid sequence NLK and comprising 3-13 amino acids from residues 244-372 of SEQ ID NO:02.