	US 12,247,050 B2
	α-sheet polypeptides and their use
Valerie Daggett, Seattle, WA (US); Dylan Shea, Seattle, WA (US); and Alissa Bleem, Seattle, WA (US)
Assigned to UNIVERSITY OF WASHINGTON, Seattle, WA (US)
Filed by University of Washington, Seattle, WA (US)
Filed on May 20, 2022, as Appl. No. 17/749,969.
Claims priority of provisional application 63/224,815, filed on Jul. 22, 2021.
Prior Publication US 2023/0048960 A1, Feb. 16, 2023
Int. Cl. C07K 14/00 (2006.01); A61K 9/70 (2006.01); A61K 38/17 (2006.01); A61P 25/28 (2006.01); C07K 7/06 (2006.01); C07K 7/08 (2006.01)

CPC C07K 14/001 (2013.01) [A61K 9/7007 (2013.01); A61K 38/1787 (2013.01); A61P 25/28 (2018.01); C07K 7/06 (2013.01); C07K 7/08 (2013.01)]

25 Claims

1. An α-sheet polypeptide multimer, comprising:

two monomeric α-sheet polypeptides that are covalently linked,

wherein each monomeric α-sheet polypeptide comprises the amino acid sequence of rGeMnLsWmneyyGwTmNmKcGr (SEQ ID NO:25) or its reverse chiral counterpart,

wherein residues in lower-case are D amino acids, residues in upper case are L amino acids, and G residues are achiral.