US 12,247,048 B2
Process for the preparation of cortexolone 17α-propionate and new hydrated crystalline form thereof
Ponzinibi Matteo, Lodi (IT); Roberto Arosio, Civate (IT); Brusasca Marco, Valenza (IT); and Di Giacomo Mario, Cenate Sotto (IT)
Assigned to Farmabios S.P.A., (IT)
Filed by FARMABIOS S.P.A., Gropello Cairoli (IT)
Filed on Mar. 30, 2022, as Appl. No. 17/708,159.
Claims priority of application No. 102021000008429 (IT), filed on Apr. 6, 2021.
Prior Publication US 2022/0324901 A1, Oct. 13, 2022
Int. Cl. C07J 5/00 (2006.01)
CPC C07J 5/0053 (2013.01) [C07B 2200/13 (2013.01)] 1 Claim
 
1. A hydrated crystalline form of cortexolone 17a- propionate of formula (I) characterized by:
(a) the following XRPD peaks at about 4.80; 11.36; 11.70; 12.29; 12.95; 14.44; 14.84; 15. 93; 16.09; 16.31; 17.20; 19.56; 20.58; 22.82±0,2° 2θ or according to FIG. 1;
(b) the IR spectrum according to FIG. 2; or
(c) the DSC thermogram according to FIG. 3.