US 12,247,036 B2
Tricyclic compounds for the treatment of cancer
Jianguo Chen, Shanghai (CN); Lei Guo, Shanghai (CN); Haixia Liu, Shanghai (CN); Hong Shen, Shanghai (CN); Junwei Xi, Shanghai (CN); Weixing Zhang, Shanghai (CN); Dan Zhao, Shanghai (CN); and Wei Zhu, Shanghai (CN)
Assigned to Hoffmann-La Roche Inc., Little Falls, NJ (US)
Filed by Hoffmann-La Roche Inc., Little Falls, NJ (US)
Filed on Aug. 22, 2024, as Appl. No. 18/812,060.
Application 18/812,060 is a continuation of application No. PCT/CN2024/076886, filed on Feb. 8, 2024.
Claims priority of application No. PCT/CN2023/075911 (WO), filed on Feb. 14, 2023; application No. PCT/CN2023/115515 (WO), filed on Aug. 29, 2023; and application No. PCT/CN2024/074420 (WO), filed on Jan. 29, 2024.
Prior Publication US 2024/0417410 A1, Dec. 19, 2024
Int. Cl. C07D 513/22 (2006.01); A61K 31/5025 (2006.01); A61K 31/506 (2006.01); A61K 31/5377 (2006.01); A61K 31/5383 (2006.01); A61K 31/553 (2006.01); A61P 35/00 (2006.01); C07D 519/00 (2006.01)
CPC C07D 513/22 (2013.01) [A61K 31/5025 (2013.01); A61K 31/506 (2013.01); A61K 31/5377 (2013.01); A61K 31/5383 (2013.01); A61K 31/553 (2013.01); A61P 35/00 (2018.01); C07D 519/00 (2013.01)] 27 Claims
 
1. A compound of formula (Ib),

OG Complex Work Unit Chemistry
or a pharmaceutically acceptable salt thereof, wherein:
R1 is 2-oxabicyclo[2.1.1]hexanyl,
3-oxabicyclo[3.1.0]hexanyl,
6-bicyclo[3.1.0]hexanyl substituted twice by halogen,
6-tricyclo[3.1.1.03,6]heptanyl,
C3-7cycloalkyl substituted by one, two, or three substituents independently selected from C1-6alkyl, C1-6alkylpyridinyl, C1-6alkylpyrimidinyl, C1-6alkyltetrazolyl, C3-7cycloalkyl, haloC1-6alkyl, halogen, halophenyl, hydroxy, phenyl, pyrazinyl, pyridazinyl, pyridinyl, pyrimidinyl, and thiazolyl, or
tetrahydropyranyl;
R2 is 1,3,4,6,7,8,9,9a-octahydropyrido[1,2-a]pyrazinyl,
3,4,6,7,9,9a-hexahydro-1H-pyrazino[2,1-c][1,4]oxazinyl,
morpholinyl, or
piperazinyl unsubstituted or substituted by one or more substituents independently selected from C1-6alkoxyC1-6alkyl, C1-6alkyl, C3-7cycloalkyl, haloC1-6alkyl, hydroxyC1-6alkyl, morpholinylC1-6alkyl, oxetanyl, oxopyrrolidinylC1-6alkyl, and tetrahydrofuranyloxyC1-6alkyl;
R3 is H or halogen;
M is C1-6alkylene or O; and
L is C1-6alkylene, hydroxyC1-6alkylene, or haloC1-6alkylene.