US 12,247,024 B2
Process for preparing aficamten
Denise Andersen, Montara, CA (US); Matthew Pfeiffer, Salt Lake City, UT (US); Norma Tom, Belmont, CA (US); and Bradley P. Morgan, South San Francisco, CA (US)
Assigned to CYTOKINETICS, INC., South San Francisco, CA (US)
Filed by Cytokinetics, Inc., South San Francisco, CA (US)
Filed on Sep. 15, 2023, as Appl. No. 18/468,636.
Application 18/468,636 is a continuation of application No. 17/816,898, filed on Aug. 2, 2022, granted, now 11,932,631.
Claims priority of provisional application 63/203,888, filed on Aug. 3, 2021.
Prior Publication US 2024/0150336 A1, May 9, 2024
This patent is subject to a terminal disclaimer.
Int. Cl. C07D 413/12 (2006.01)
CPC C07D 413/12 (2013.01) 8 Claims
 
1. A method of preparing a compound of Formula (1):

OG Complex Work Unit Chemistry
comprising:
(i) converting a compound of Formula (7)

OG Complex Work Unit Chemistry
to a compound of Formula (6)

OG Complex Work Unit Chemistry
by reacting the compound of Formula (7) with (R)-tert-butanesulfinamide;
(ii) converting the compound of Formula (6), to a compound of Formula (5)

OG Complex Work Unit Chemistry
by reacting the compound of Formula (6) with a reducing agent; and
(iii) converting the compound of Formula (5) to the compound of Formula (1).