CPC C07D 285/24 (2013.01) [C07D 417/10 (2013.01); A61K 45/06 (2013.01)] | 22 Claims |
1. A compound of Formula 1,
![]() or a tautomer thereof, or a pharmaceutically acceptable salt of the compound of Formula 1 or tautomer thereof, wherein:
L is selected from a bond and C1-4 alkanediyl;
R1 is selected from
(a) C1-4 alkyl which is substituted with from 0 to 3 optional substituents independently selected from halo, hydroxy, cyano, C1-4 alkoxy, amino and aminocarbonyl, wherein each of the C1-4 alkoxy optional substituents is independently substituted with from 0 to 3 substituents independently selected from halo, and wherein each of the amino and aminocarbonyl optional substituents is independently substituted with from 0 to 2 substituents independently selected from C1-4 alkyl; and
(b) a cyclic group selected from C3-8 cycloalkyl, C2-9 heterocyclyl, C6-14 aryl and C1-9 heteroaryl, wherein the cyclic group is substituted with from 0 to 3 optional substituents independently selected from halo, hydroxy, cyano, C1-4 alkyl, C1-4 alkoxy, amino and aminocarbonyl, wherein each of the C1-4 alkyl and C1-4 alkoxy optional substituents is independently substituted with from 0 to 3 substituents independently selected from halo, and wherein each of the amino and aminocarbonyl optional substituents is independently substituted with from 0 to 2 substituents independently selected from C1-4 alkyl;
R2 is a cyclic group selected from C3-8 cycloalkyl, C2-9 heterocyclyl, C6-14 aryl and C1-9 heteroaryl, wherein the cyclic group is substituted with from 0 to 3 optional substituents independently selected from halo, hydroxy, cyano, C1-4 alkyl, C1-4 alkoxy, amino, C3-8 cycloalkyl and C3-5 heterocyclyl, provided the cyclic group has no more than one optional substituent which is selected from C3-8 cycloalkyl and C3-5 heterocyclyl, and wherein each of the C1-4 alkyl, C1-4 alkoxy, C3-8 cycloalkyl and C3-5 heterocyclyl optional substituents is independently substituted with from 0 to 3 substituents independently selected from halo, and wherein the amino optional substituent is independently substituted with from 0 to 2 substituents independently selected from C1-4 alkyl;
R3, R4, and R5 are each independently selected from hydrogen, halo, cyano, and C1-3 alkyl;
wherein each of the aforementioned heterocyclyl and heteroaryl moieties independently has 1 to 4 heteroatoms as ring members, each independently selected from N, O, and S.
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