US 12,246,195 B2
Pre-treatment tissue sensitization for focused ultrasound procedures
Yoav Levy, Hinanit (IL); Israel Schuster, Kiryat Tivon (IL); and Shahar Rinott, Haifa (IL)
Assigned to INSIGHTEC, LTD., Tirat Carmel (IL)
Appl. No. 17/768,177
Filed by INSIGHTEC, LTD., Tirat Carmel (IL)
PCT Filed Oct. 12, 2020, PCT No. PCT/IB2020/000845
§ 371(c)(1), (2) Date Apr. 11, 2022,
PCT Pub. No. WO2021/069971, PCT Pub. Date Apr. 15, 2021.
Claims priority of provisional application 62/913,772, filed on Oct. 11, 2019.
Prior Publication US 2024/0091565 A1, Mar. 21, 2024
Int. Cl. A61N 7/02 (2006.01); A61B 90/00 (2016.01); A61N 7/00 (2006.01)
CPC A61N 7/02 (2013.01) [A61B 2090/374 (2016.02); A61N 2007/0039 (2013.01); A61N 2007/0095 (2013.01)] 31 Claims
OG exemplary drawing
 
1. A system for treating target tissue, the system comprising:
an ultrasound transducer for delivering acoustic energy to the target tissue; and
a controller, configured to (i) generate a priming sequence of sonication pulses for driving the ultrasound transducer to deliver acoustic energy to the target tissue in accordance with the priming sequence, (ii) pause driving the ultrasound transducer for a delay interval, and (iii) generate a series of treatment sequences of sonication pulses for driving the ultrasound transducer to deliver acoustic energy to the target tissue in accordance with the series of treatment sequences,
wherein the treatment sequences have sonication intervals therebetween and the delay interval is larger than a largest sonication interval by a predetermined factor, and wherein the delay interval occurs between steps (i) and (iii).