US 12,246,179 B2
Non-regular electrical stimulation patterns for treating neurological disorders
Warren M. Grill, Jr., Chapel Hill, NC (US); Alan D. Dorval, II, Salt Lake City, UT (US); and Robert Strother, Willoughby Hills, OH (US)
Assigned to Duke University, Durham, NC (US)
Filed by Duke University, Durham, NC (US)
Filed on May 24, 2021, as Appl. No. 17/327,836.
Application 17/327,836 is a division of application No. 14/529,291, filed on Oct. 31, 2014, granted, now 11,013,924.
Application 14/529,291 is a continuation in part of application No. 13/897,504, filed on May 20, 2013, granted, now 9,259,579, issued on Feb. 16, 2016.
Application 13/897,504 is a continuation of application No. 12/587,295, filed on Oct. 5, 2009, granted, now 8,447,405, issued on May 21, 2013.
Claims priority of provisional application 61/102,575, filed on Oct. 3, 2008.
Prior Publication US 2021/0275820 A1, Sep. 9, 2021
Int. Cl. A61N 1/36 (2006.01); A61N 1/05 (2006.01)
CPC A61N 1/36178 (2013.01) [A61N 1/36067 (2013.01); A61N 1/36082 (2013.01); A61N 1/0534 (2013.01); A61N 1/36171 (2013.01); A61N 1/36196 (2013.01)] 16 Claims
OG exemplary drawing
 
1. A system for neurological tissue stimulation comprising:
an electrode implantable in a targeted tissue;
a pulse generator operably coupled to the electrode, wherein the pulse generator applies electrical stimulation, the electrical stimulation comprising:
a waveform shape, wherein the waveform shape is derived based upon application of a genetic algorithm and programmed into the pulse generator; and
a temporal pattern of stimulation related to the waveform shape and comprising a repeating succession of non-regular pulse trains, each pulse train comprising a plurality of pulses having non-regular, non-random, differing inter-pulse intervals therebetween, the pulse train repeating in succession to treat a neurological symptom.