US 12,246,176 B1
System and method for the activation of active ion transporters without the consumption of adenosine triphosphate (ATP) molecules for the treatment of limb ischemia
Wei Chen, Tampa, FL (US); and Ruisheng Liu, Tampa, FL (US)
Assigned to WR Biotech, LLC, Tampa, FL (US)
Filed by WR Biotech, LLC, Tampa, FL (US)
Filed on Mar. 17, 2023, as Appl. No. 18/185,523.
Claims priority of provisional application 63/320,947, filed on Mar. 17, 2022.
Int. Cl. A61N 1/36 (2006.01); A61N 1/04 (2006.01); A61N 1/32 (2006.01)
CPC A61N 1/36034 (2017.08) [A61N 1/323 (2013.01); A61N 1/0408 (2013.01); A61N 1/0476 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A method for controlling Na/K pump molecules for the treatment of limb ischemia, the method comprising:
applying an oscillating electric field to an ischemia limb comprising Na/K pump molecules, wherein the oscillating electric field comprises three serially applied phases and wherein applying the oscillating electric field comprises;
applying a synchronization phase to synchronize the Na/K pump molecules down to individual steps within a running cycle at an Na/K pump molecule physiological turnover rate with a net-consumption of adenosine triphosphate (ATP) substantially equal to zero;
applying a modulation phase to up modulate the synchronized Na/K pump molecules to a predetermined target turnover rate; and
applying a maintenance phase to maintain the synchronized Na/K pump molecules at the predetermined target turnover rate for a predetermined duration of time.