US 12,246,154 B2
Microarray applicator
David J. Wirtanen, St. Paul, MN (US); Kevin L Puckett, St. Paul, MN (US); James L. Schug, St. Paul, MN (US); and David J. White, St. Paul, MN (US)
Assigned to Kindeva Drug Delivery L.P., St. Paul, MN (US)
Appl. No. 16/956,217
Filed by KINDEVA DRUG DELIVERY L.P., St. Paul, MN (US)
PCT Filed Dec. 4, 2018, PCT No. PCT/IB2018/059637
§ 371(c)(1), (2) Date Jun. 19, 2020,
PCT Pub. No. WO2019/123072, PCT Pub. Date Jun. 27, 2019.
Claims priority of provisional application 62/607,567, filed on Dec. 19, 2017.
Prior Publication US 2020/0391018 A1, Dec. 17, 2020
Int. Cl. A61M 37/00 (2006.01); A61K 9/00 (2006.01); A61K 9/70 (2006.01); A61M 25/00 (2006.01)
CPC A61M 37/0015 (2013.01) [A61K 9/0021 (2013.01); A61K 9/7023 (2013.01); A61M 2025/0093 (2013.01); A61M 2037/0023 (2013.01); A61M 2037/0061 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A microarray applicator comprising:
a housing, the housing comprising:
a first major surface configured to be positioned towards skin and defining a bottom of the housing;
a second major surface opposite the first major surface and defining a top of the housing;
a cavity extending through the first and second major surfaces;
an interior surface defining the cavity, the interior surface comprising one or more ridges, each ridge of the one or more ridges comprising a ridge width and a ridge height, wherein the ridge height is defined by a distance between the ridge and the first major surface of the housing; and
a holder located between the first and second major surfaces for holding at least part of a microarray device within the housing; and
a plunger comprising:
a top, a bottom, and one or more sides;
a first set of one or more notches located proximate to the bottom of the plunger, each notch of the first set of one or more notches being located substantially a same distance from the bottom of the plunger, and extending a first depth into the one or more sides of the plunger, wherein each notch of the first set of one or more notches comprises a profile that is substantially rotationally symmetric about an axis substantially normal to the one or more sides of the plunger adjacent to the notch; and
a second set of one or more notches located proximate to the top of the plunger, each notch of the second set of one or more notches being located substantially a same distance from the top of the plunger, and extending a second depth into the one or more sides of the plunger wherein each notch of the second set of one or more notches comprises a profile that is substantially rotationally symmetric about an axis substantially normal to the one or more sides of the plunger adjacent to the notch;
wherein the second depth is equal to or less than the first depth, the second depth is equal to or greater than the ridge width, a distance between the first set of one or more notches and the second set of one or more notches is greater than the ridge height, and the plunger is slidably engageable with the cavity in the housing to be positionable at a first position wherein the first set of one or more notches is engaged with the one or more ridges in the housing and the bottom of the plunger does not extend below the first major surface of the housing, and at a second position wherein the second set of one or more notches is engaged with the one or more ridges in the housing and the bottom of the plunger extends below the first major surface of the housing, and
wherein when the plunger is at the first position, releasing the first set of one or more notches from engagement with the one or more ridges requires substantially the same first force in either direction, and when the plunger is at the second position, releasing the second set of one or more notches from engagement with the one or more ridges requires substantially the same second force in either direction.