| CPC A61M 11/008 (2014.02) [B01F 25/105 (2022.01); B01F 25/4521 (2022.01); B01F 35/7139 (2022.01); B29C 49/20 (2013.01); B29C 49/42809 (2022.05); B65D 25/082 (2013.01); B65D 81/3255 (2013.01); A61M 2205/075 (2013.01); A61M 2205/273 (2013.01); A61M 2207/00 (2013.01); A61M 2210/0618 (2013.01); B01F 2101/2202 (2022.01); B29C 2049/2008 (2013.01); B29C 49/46 (2013.01); B29C 2049/4664 (2013.01); B29L 2031/712 (2013.01)] | 23 Claims |

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1. A production method of a pre-filled or pre-fillable with one or more substances, comprising:
a squeezable activation compartment for containing said substances;
a dispensing compartment with a first portion having at least one dispensing member and a second portion fluid-dynamically connected to the activation compartment;
an activator element inside a container, having a head with a tapered closing portion and a sliding crown larger than the tapered closing portion, the sliding crown provided with one or more mixing elements;
wherein the activator element is movable between a closed position, hermetically isolating the activation compartment from the dispensing compartment, and an open position, allowing fluid-dynamic communication between the compartments for substance dispensing;
wherein the production method comprising:
comprising the following steps:
increasing a temperature of said container for workability;
inserting said activator element into said container; and
centring and engaging said activator element between said activation compartment and said dispensing compartment
wherein at least one of the activation compartments and the dispensing compartments are molded by a “Blow Fill Seal” process; and
wherein the dispensing and activation compartments are formed and calibrated by inserting the activator element into the container.
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