US 12,246,114 B2
Biomedical patches with spatially arranged fibers
Matthew R. MacEwan, St. Louis, MO (US)
Assigned to Washington University, St. Louis, MO (US)
Filed by Washington University, St. Louis, MO (US)
Filed on May 12, 2020, as Appl. No. 16/872,926.
Application 16/131,887 is a division of application No. 14/429,976, granted, now 10,124,089, issued on Nov. 13, 2018, previously published as PCT/US2012/056548, filed on Sep. 21, 2012.
Application 16/872,926 is a continuation of application No. 16/540,779, filed on Aug. 14, 2019, granted, now 10,682,444.
Application 16/540,779 is a continuation of application No. 16/131,887, filed on Sep. 14, 2018, granted, now 10,441,685, issued on Oct. 15, 2019.
Prior Publication US 2021/0001014 A1, Jan. 7, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. A61L 31/04 (2006.01); A61F 13/02 (2024.01); A61L 15/26 (2006.01); A61L 15/44 (2006.01); A61L 15/64 (2006.01); A61L 27/18 (2006.01); A61L 27/54 (2006.01); A61L 27/58 (2006.01); A61L 27/60 (2006.01); B29C 48/18 (2019.01); B32B 5/02 (2006.01); B32B 5/26 (2006.01); B32B 7/02 (2019.01); B32B 7/12 (2006.01); D01D 5/00 (2006.01); D04H 1/728 (2012.01); D04H 3/16 (2006.01)
CPC A61L 31/04 (2013.01) [A61L 15/26 (2013.01); A61L 15/44 (2013.01); A61L 15/64 (2013.01); A61L 27/18 (2013.01); A61L 27/54 (2013.01); A61L 27/58 (2013.01); A61L 27/60 (2013.01); B29C 48/18 (2019.02); B32B 5/022 (2013.01); B32B 5/26 (2013.01); B32B 7/02 (2013.01); B32B 7/12 (2013.01); D01D 5/0007 (2013.01); D01D 5/0038 (2013.01); D01D 5/0061 (2013.01); D01D 5/0076 (2013.01); D04H 1/728 (2013.01); D04H 3/16 (2013.01); A61F 13/02 (2013.01); A61L 2300/414 (2013.01); A61L 2400/12 (2013.01); A61L 2400/18 (2013.01); A61L 2430/20 (2013.01); A61L 2430/32 (2013.01); B32B 2250/20 (2013.01); B32B 2262/0276 (2013.01); B32B 2307/518 (2013.01); B32B 2307/54 (2013.01); B32B 2307/726 (2013.01); B32B 2307/7265 (2013.01); B32B 2556/00 (2013.01); D10B 2509/00 (2013.01)] 22 Claims
OG exemplary drawing
 
1. A three-dimensional electrospun nanofiber scaffold for facilitating tissue repair, the three-dimensional electrospun nanofiber scaffold comprising:
a first plurality of deposited electrospun polymeric nanofibers; and
a second plurality of deposited electrospun polymeric nanofibers,
the second plurality of deposited electrospun polymeric nanofibers being coupled to the first plurality of electrospun polymeric nanofibers,
wherein at least some of the second plurality of deposited electrospun polymeric nanofibers are deposited over a portion of the first plurality of electrospun polymeric nanofibers to form one or more regions comprising a spatial variation between fibers on an outer surface of the three-dimensional electrospun nanofiber scaffold that is different from one or more other regions not on the outer surface of the three-dimensional electrospun nanofiber scaffold,
wherein at least some of the second plurality of deposited electrospun polymeric nanofibers are commingled with the first plurality of electrospun polymeric nanofibers within the first portion,
the three-dimensional electrospun nanofiber scaffold further comprising a surface, the surface comprising a surface pattern formed by one or more of the first plurality of deposited electrospun polymeric nanofibers or the second plurality of deposited electrospun polymeric nanofibers, and
the three-dimensional electrospun nanofiber scaffold further comprising a void.