US 12,246,113 B2
Fabrication of porous scaffolds using additive manufacturing with potential applications in bone tissue engineering
Hernan Lara Padilla, Columbus, OH (US); David Dean, Columbus, OH (US); and Ciro Rodriguez, Columbus, OH (US)
Assigned to Ohio State Innovation Foundation, Columbus, OH (US)
Appl. No. 17/266,807
Filed by Ohio State Innovation Foundation, Columbus, OH (US)
PCT Filed Aug. 7, 2019, PCT No. PCT/US2019/045588
§ 371(c)(1), (2) Date Feb. 8, 2021,
PCT Pub. No. WO2020/033607, PCT Pub. Date Feb. 13, 2020.
Claims priority of provisional application 62/715,596, filed on Aug. 7, 2018.
Prior Publication US 2021/0316367 A1, Oct. 14, 2021
Int. Cl. B33Y 10/00 (2015.01); A61L 27/16 (2006.01); A61L 27/56 (2006.01); B22F 10/12 (2021.01); B22F 10/14 (2021.01); B22F 10/18 (2021.01); B22F 10/25 (2021.01); B22F 10/28 (2021.01); B22F 10/36 (2021.01); B22F 10/38 (2021.01); B22F 10/85 (2021.01); B22F 12/90 (2021.01); B29C 64/165 (2017.01); B29C 64/393 (2017.01); B33Y 50/02 (2015.01); B33Y 80/00 (2015.01); C12M 1/00 (2006.01); C12M 3/00 (2006.01)
CPC A61L 27/56 (2013.01) [A61L 27/16 (2013.01); B22F 10/12 (2021.01); B22F 10/14 (2021.01); B22F 10/18 (2021.01); B22F 10/25 (2021.01); B22F 10/28 (2021.01); B22F 10/36 (2021.01); B22F 10/38 (2021.01); B22F 10/85 (2021.01); B22F 12/90 (2021.01); B29C 64/165 (2017.08); B29C 64/393 (2017.08); B33Y 10/00 (2014.12); B33Y 50/02 (2014.12); B33Y 80/00 (2014.12); C12M 23/44 (2013.01); C12M 29/10 (2013.01); A61L 2430/02 (2013.01)] 18 Claims
OG exemplary drawing
 
1. A method for optimizing a stereolithographic additive manufacturing process for the production of a three-dimensional object using a stereolithographic additive manufacturing device, the method comprising:
(a) actuating a build plate to separate a test layer from the build plate;
(b) measuring a separation force required to separate the test layer from the build plate with a force sensor during step (a);
(c) repeating steps (a) and (b) to form one or more additional layers having one or more additional cross-sectional areas until there is a failure of interlayer binding of any two of the layers upon activation of the build plate;
(d) calculating an interlayer green strength by dividing the separation force measured for a most recent additional layer manufactured during step (c) upon failure of interlayer binding by the additional cross-sectional area of the most recent additional layer; and
(e) calculating a probability of structural failure of the test layer by comparing the separation force of the test layer with the interlayer green force;
wherein if the separation force of the test layer is greater than the interlayer green force, then a resin composition is modified, a cross-sectional overlap between the test layer and one or more adjacent layers is increased, an incident energy generated by the stereolithographic additive manufacturing device during the stereolithographic additive manufacturing process is modified, or a combination thereof.