US 12,246,109 B2
Regeneration of tendon and tendon sheath, restoration material, and use of restoration material
Toshiko Yoshida, Toyama (JP); Motonori Okabe, Toyama (JP); Ryusuke Osada, Toyama (JP); Mineyuki Zukawa, Toyama (JP); and Masahiko Arakawa, Nagano (JP)
Assigned to Toshiko Yoshida, Toyama (JP); Motonori Okabe, Toyama (JP); Ryusuke Osada, Toyama (JP); Mineyuki Zukawa, Toyama (JP); and SAKURA SEIKI CO., LTD., Nagano (JP)
Appl. No. 17/257,918
Filed by Toshiko Yoshida, Toyama (JP); Motonori Okabe, Toyama (JP); Ryusuke Osada, Toyama (JP); Mineyuki Zukawa, Toyama (JP); and SAKURA SEIKI CO., LTD., Nagano (JP)
PCT Filed Aug. 30, 2019, PCT No. PCT/JP2019/034052
§ 371(c)(1), (2) Date Jan. 5, 2021,
PCT Pub. No. WO2020/045608, PCT Pub. Date Mar. 5, 2020.
Claims priority of application No. 2018-174244 (JP), filed on Aug. 30, 2018.
Prior Publication US 2021/0283306 A1, Sep. 16, 2021
Int. Cl. A61L 27/36 (2006.01)
CPC A61L 27/3604 (2013.01) [A61L 27/3662 (2013.01); A61L 27/3691 (2013.01); A61L 2430/10 (2013.01)] 3 Claims
 
1. A restoration material, characterized in that the restoration material is a dried amniotic membrane, which is used as a regeneration material for a tendon and a tendon sheath and is obtained by subjecting a fresh amniotic membrane wrapping a fetus of an animal including a human, while heating the fresh amniotic membrane to 50° C. by far-infrared rays:
(1) depressurization for 180 seconds;
(2) pressure recovery for 30 seconds and microwave irradiation at 0.1 kW;
(3) depressurization for 180 seconds; and
(4) repeating of the processes of (2) and (3), and when ultimate pressure after the depressurization in (3) becomes 0.30 kPa to 0.35 kPa, recovering of the pressure to atmospheric pressure to complete a drying treatment,
wherein the dried amniotic membrane has been dehydrated and dried so that the dried amniotic membrane can be stored in a dry atmosphere in a sterile state, and in which epithelial cells, a basement membrane, and a connective tissue constituting the fresh amniotic membrane are retained in an amniotic membrane resulting from rehydration by immersion in water or a buffer solution, and
after a completely ruptured tendon accompanied with bone injury is sutured, disposed, as a regeneration material of the completely ruptured tendon, between the ruptured tendon and an injured bone, and repairs the tendon while suppressing adhesion involving a bone at a site surrounding the sutured tendon without inhibiting bone formation at the bone injury part.