| CPC A61K 9/7084 (2013.01) [A61K 9/0014 (2013.01); A61K 45/06 (2013.01); A61K 47/18 (2013.01)] | 24 Claims |
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1. A formulation for trans-epithelial membrane delivery of an active ingredient to a mammal; the formulation comprises:
a) at least one first penetration agent, wherein the at least one first penetration agent is present in an amount ranging from 0.01% w/w to 2.0% w/w, wherein the at least one penetration agent is acetylcysteine, N-acetylcysteine, L-cysteine, ambroxol, bromhexine, carbocisteine, erdosteine, mecysteine, dornase alfa, althea extract, Marshmallow root, bromelain, thyme, salt water, eucalyptol, rosemary extract, cineole, peppermint, frankincense, oregano, bergamot, nutmeg, cypress, camphene, geranium, pelargonium sidoide, cinnamon, lemon, citrus, d-limonene, 1-limonene, lavender, lemon grass, chamomile, basil or a combination thereof;
b) at least one basement membrane disruptor, wherein the at least one basement membrane disruptor is present in an amount ranging from 0.2% w/w to 10% w/w, wherein the at least one basement membrane disruptor is a serine protease, a cysteine protease, a threonine protease, an aspartic protease, a glutamic protease, a lipase, a lactase, an ox bile extract, a phytase, a pancreatin, a pepsin, Chymotrypsin A, α-trypsin, and β-trypsin, papain, papaya, bromelain, pineapple, or a combination thereof;
c) at least one vaso-modulator present in an amount ranging from 0.001% w/w to 15% w/w; and
d) at least one active ingredient;
wherein the formulation has a pH of between about 5.0 and about 6.5; and wherein the formulation allows for penetration of the active ingredient past the basement membrane.
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