US 12,246,057 B2
Transmembrane stem cell factor (tm-SCF) lipid nanocarriers and methods of use thereof
Aaron Baker, Austin, TX (US); and Eri Takematsu, Austin, TX (US)
Assigned to BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM, Austin, TX (US)
Appl. No. 17/047,135
Filed by BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM, Austin, TX (US)
PCT Filed Apr. 12, 2019, PCT No. PCT/US2019/027192
§ 371(c)(1), (2) Date Oct. 13, 2020,
PCT Pub. No. WO2019/200240, PCT Pub. Date Oct. 17, 2019.
Claims priority of provisional application 62/657,153, filed on Apr. 13, 2018.
Prior Publication US 2021/0145931 A1, May 20, 2021
Int. Cl. A61P 43/00 (2006.01); A61K 38/17 (2006.01); A61K 47/69 (2017.01)
CPC A61K 38/177 (2013.01) [A61K 47/6925 (2017.08); A61P 43/00 (2018.01)] 12 Claims
 
1. A lipid nanodisc composition comprising: a membrane scaffold protein; a lipid; and a transmembrane stem cell factor (tmSCF) polypeptide; wherein the composition is encapsulated in a biodegradable microcapsule or microbead wherein the composition is effective in treating peripheral vascular disease (PVP) or promoting angiogenesis.