US 12,246,027 B2
Compositions of bile acids and phenylbutyrate compounds
Joshua Cohen, Canton, MA (US); Justin Klee, Cambridge, MA (US); and David Wai Fung Ma, Whitby (CA)
Assigned to Amylyx Pharmaceuticals, Inc., Cambridge, MA (US)
Filed by Amylyx Pharmaceuticals, Inc., Cambridge, MA (US)
Filed on Dec. 8, 2022, as Appl. No. 18/077,296.
Application 18/077,296 is a continuation of application No. 17/557,626, filed on Dec. 21, 2021, granted, now 11,559,533.
Application 17/557,626 is a continuation of application No. 16/940,102, filed on Jul. 27, 2020, granted, now 11,583,542.
Claims priority of provisional application 63/030,793, filed on May 27, 2020.
Claims priority of provisional application 62/948,756, filed on Dec. 16, 2019.
Prior Publication US 2023/0210869 A1, Jul. 6, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 31/4709 (2006.01); A61K 9/06 (2006.01); A61K 9/16 (2006.01); A61K 31/192 (2006.01); A61K 31/575 (2006.01); A61K 47/02 (2006.01); A61K 47/10 (2017.01); A61K 47/12 (2006.01); A61K 47/26 (2006.01); A61P 17/00 (2006.01); A61P 17/04 (2006.01); A61P 17/10 (2006.01); A61P 31/04 (2006.01)
CPC A61K 31/575 (2013.01) [A61K 9/1652 (2013.01); A61K 31/192 (2013.01); A61K 47/02 (2013.01); A61K 47/26 (2013.01)] 11 Claims
 
1. A composition comprising about 27% to about 32% w/w of sodium phenylbutyrate, about 8% to about 12% w/w of taurursodiol (TURSO), about 14% to about 17% w/w of dextrates, about 3.5% to about 4.5% w/w of sorbitol, about 25% to about 32% w/w of maltodextrin, and about 0.05% to about 1.5% w/w of porous silica, wherein the sodium phenylbutyrate and the TURSO have a ratio by weight of about 3:1, wherein the composition has a measurable Carr's index of about 24 or less, and wherein the composition is prepared by a method comprising dry granulation.