US 12,246,018 B2
Gamma polyglutamated pemetrexed and uses thereof
Clet Niyikiza, Gulph Mills, PA (US); and Victor Mandla Moyo, Ringoes, NJ (US)
Assigned to L.E.A.F. HOLDINGS GROUP LLC, Gulph Mills, PA (US)
Appl. No. 16/967,234
Filed by L.E.A.F. HOLDINGS GROUP LLC, Gulph Mills, PA (US)
PCT Filed Feb. 7, 2019, PCT No. PCT/US2019/017000
§ 371(c)(1), (2) Date Aug. 4, 2020,
PCT Pub. No. WO2019/157145, PCT Pub. Date Aug. 15, 2019.
Claims priority of provisional application 62/764,951, filed on Aug. 17, 2018.
Claims priority of provisional application 62/764,945, filed on Aug. 17, 2018.
Claims priority of provisional application 62/702,779, filed on Jul. 24, 2018.
Claims priority of provisional application 62/702,774, filed on Jul. 24, 2018.
Claims priority of provisional application 62/662,372, filed on Apr. 25, 2018.
Claims priority of provisional application 62/630,625, filed on Feb. 14, 2018.
Claims priority of provisional application 62/627,732, filed on Feb. 7, 2018.
Prior Publication US 2021/0161899 A1, Jun. 3, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 31/519 (2006.01); A61K 9/127 (2006.01); A61K 9/1271 (2025.01); A61K 9/1277 (2025.01); A61K 31/282 (2006.01); A61K 39/395 (2006.01); A61K 47/26 (2006.01); A61K 47/64 (2017.01); A61K 47/69 (2017.01); A61P 35/00 (2006.01)
CPC A61K 31/519 (2013.01) [A61K 9/1271 (2013.01); A61K 9/1277 (2013.01); A61K 31/282 (2013.01); A61K 39/3955 (2013.01); A61K 47/26 (2013.01); A61K 47/645 (2017.08); A61K 47/6913 (2017.08); A61P 35/00 (2018.01)] 26 Claims
OG exemplary drawing
 
1. A liposomal composition comprising a gamma polyglutamated pemetrexed encapsulated by a liposome, wherein the gamma polyglutamated pemetrexed has 4, 5, 2-10, 4-6, or more than 5, glutamyl groups having a gamma carboxyl group linkage, and wherein the liposome is pegylated, wherein the liposome does not contain a targeting moiety having specific affinity for a surface antigen on a target cell,
wherein the liposome does not contain a cell penetrating peptide and does not contain a mitochondria penetrating peptide,
wherein the liposome has a zeta potential that is less than or equal to zero, between 0 to −150 mV, or between −30 to −50 mV, and
wherein the liposome is capable of delivering the gamma polyglutamated pemetrexed directly into a cell.