US 12,246,009 B2
Compositions and methods for treating neurodegenerative, myodegenerative, and lysosomal storage disorders
Christian Wolf, Washington, DC (US); Balaraman Kaluvu, Washington, DC (US); and Charbel Moussa, Washington, DC (US)
Assigned to Georgetown University, Washington, DC (US)
Appl. No. 17/295,553
Filed by GEORGETOWN UNIVERSITY, Washington, DC (US)
PCT Filed Nov. 20, 2019, PCT No. PCT/US2019/062387
§ 371(c)(1), (2) Date May 20, 2021,
PCT Pub. No. WO2020/106825, PCT Pub. Date May 28, 2020.
Claims priority of provisional application 62/769,791, filed on Nov. 20, 2018.
Prior Publication US 2021/0369687 A1, Dec. 2, 2021
Int. Cl. A61K 31/4365 (2006.01); A61K 31/13 (2006.01); A61K 31/198 (2006.01); A61K 31/27 (2006.01); A61K 31/428 (2006.01); A61K 31/445 (2006.01); A61K 31/4745 (2006.01); A61K 31/519 (2006.01); A61K 35/28 (2015.01); A61K 45/06 (2006.01); A61K 48/00 (2006.01); A61P 25/28 (2006.01); C07D 495/04 (2006.01)
CPC A61K 31/4365 (2013.01) [A61K 31/13 (2013.01); A61K 31/198 (2013.01); A61K 31/27 (2013.01); A61K 31/428 (2013.01); A61K 31/445 (2013.01); A61K 31/4745 (2013.01); A61K 31/519 (2013.01); A61K 35/28 (2013.01); A61K 45/06 (2013.01); A61P 25/28 (2018.01); C07D 495/04 (2013.01); A61K 48/00 (2013.01)] 28 Claims
 
1. A compound having the following formula:

OG Complex Work Unit Chemistry
wherein
X is CH;
R1 is —CH3;
Z is heteroaryl, heterocyclyl, or NR3R4, wherein
R3 and R4 are independently H, C1-3 alkyl, C1-3 alkoxy, or unsubstituted phenyl, or a pharmaceutically acceptable salt thereof.