	US 12,245,919 B2
	Medical adhesives for quick release of antimicrobials
Neal Carty, Chicago, IL (US); and Jilin Zhang, Mentor, OH (US)
Assigned to Avery Dennison Corporation, Mentor, OH (US)
Appl. No. 17/251,160
Filed by Avery Dennison Corporation, Glendale, CA (US)
PCT Filed Jun. 12, 2019, PCT No. PCT/US2019/036771 § 371(c)(1), (2) Date Dec. 10, 2020, PCT Pub. No. WO2019/241391, PCT Pub. Date Dec. 19, 2019.
Claims priority of provisional application 62/684,459, filed on Jun. 13, 2018.
Prior Publication US 2021/0259890 A1, Aug. 26, 2021
Int. Cl. A61F 13/0246 (2024.01); A61F 13/00 (2024.01); A61L 15/18 (2006.01); A61L 15/28 (2006.01); A61L 15/46 (2006.01); A61L 15/58 (2006.01); C08L 1/02 (2006.01)

CPC A61F 13/0253 (2013.01) [A61L 15/18 (2013.01); A61L 15/28 (2013.01); A61L 15/46 (2013.01); A61L 15/58 (2013.01); C08L 1/02 (2013.01); A61F 2013/00663 (2013.01); A61F 2013/00702 (2013.01); A61F 2013/0091 (2013.01); A61L 2300/206 (2013.01); A61L 2300/232 (2013.01)]

30 Claims

1. An adhesive composition comprising:

at least one adhesive, wherein the at least one adhesive is an alcohol-functionalized acrylic adhesive;

at least one phase-separated hydrophilic material selected from the group consisting of silicon dioxide, titanium dioxide, and combinations thereof; and

at least one bioactive compound comprising an antimicrobial agent,

wherein

a concentration of the at least one bioactive compound in the adhesive composition ranges from about 1 wt % to about 10 wt %;

wherein a concentration of the at least one phase-separated hydrophilic material in the adhesive composition ranges from about 7 wt % to about 15 wt %;

wherein a concentration of the at least one adhesive in the at least one adhesive composition ranges from about 80 wt % to about 90 wt %, and

wherein the adhesive composition has a release rate of the at least one bioactive compound into water, and wherein the release rate is at least about 50 μg/cm²within 90 minutes of contact of the adhesive composition with water.