| CPC A61B 5/02158 (2013.01) [A61B 5/02007 (2013.01); A61B 5/6851 (2013.01); A61B 5/6852 (2013.01); A61B 5/7239 (2013.01); A61B 5/352 (2021.01)] | 18 Claims |

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1. A system comprising:
at least one intravascular pressure-sensing instrument comprising at least one of a catheter or a guide wire; and
a processor configured for communication with the at least one intravascular pressure-sensing instrument,
wherein the processor configured to:
obtain a plurality of pressure measurements for a cardiac cycle of a patient from the at least one intravascular pressure-sensing instrument while the at least one intravascular pressure-sensing instrument is positioned within a vessel, wherein the plurality of pressure measurements corresponds to a pressure waveform;
for the cardiac cycle, perform a calculation for each time period of a plurality of time periods of the pressure waveform, thereby resulting in a plurality of calculations for the plurality of time periods, respectively, wherein a duration of each time period is shorter than an entirety of the cardiac cycle and longer than a single time point, wherein each time period is shifted relative to an adjacent time period by an amount of time less than the duration of each time period such that each time period partially overlaps at least one other time period, wherein the plurality of time periods are arranged consecutively such that the plurality of time periods move left to right along the pressure waveform;
select a subset of the plurality of the pressure measurements based on the plurality of calculations;
determine a pressure ratio based on the subset of the plurality of pressure measurements; and
output the pressure ratio to a display device in communication with the processor.
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