US 12,245,840 B2
Modular system for multi-modal imaging and analysis
Ralph S. Dacosta, Etobicoke (CA); Simon Treadwell, Toronto (CA); Connor Wright, Toronto (CA); Kimberlyn Dampitan, Mississauga (CA); Todd Daynes, Aurora (CA); Todd Meaney, Thornhill (CA); Carl Annis, Oakville (CA); Danielle Dunham, Toronto (CA); and Nitesh Mistry, Toronto (CA)
Assigned to MolecuLight Inc., Toronto (CA)
Appl. No. 17/423,447
Filed by MolecuLight Inc., Toronto (CA)
PCT Filed Jan. 17, 2020, PCT No. PCT/IB2020/050385
§ 371(c)(1), (2) Date Jul. 15, 2021,
PCT Pub. No. WO2020/148726, PCT Pub. Date Jul. 23, 2020.
Claims priority of provisional application 62/793,842, filed on Jan. 17, 2019.
Prior Publication US 2022/0061671 A1, Mar. 3, 2022
Int. Cl. A61B 5/00 (2006.01); A61B 46/17 (2016.01); A61B 5/01 (2006.01)
CPC A61B 5/0071 (2013.01) [A61B 5/0013 (2013.01); A61B 5/0035 (2013.01); A61B 5/0077 (2013.01); A61B 5/0086 (2013.01); A61B 5/7445 (2013.01); A61B 46/17 (2016.02); A61B 5/01 (2013.01); A61B 2560/0214 (2013.01); A61B 2560/0233 (2013.01); A61B 2560/0242 (2013.01); A61B 2560/0443 (2013.01); A61B 2562/0233 (2013.01)] 79 Claims
OG exemplary drawing
 
1. A portable, handheld imaging system, comprising:
at least one excitation light source configured to emit excitation light during fluorescent imaging;
a first image sensor configured to detect fluorescent wavelengths when the imaging system is in a fluorescent imaging mode;
a first filter configured to permit passage of optical signals, responsive to illumination of a target surface with the excitation light and having a wavelength corresponding to one or more of bacterial fluorescence, bacterial autofluorescence, tissue fluorescence, and tissue autofluorescence the first filter being fixed to the first image sensor;
a white light source configured to emit white light during white light imaging;
a second image sensor configured to detect image data responsive to illumination of the target surface with the white light when the imaging system is in a white light imaging mode;
a second filter configured to permit passage of optical signals, responsive to illumination of the target surface with the white light and having a wavelength in the visible light range, the second filter being fixed to the second image sensor;
a third image sensor configured to detect image data responsive to illumination of the target surface with white light when the imaging system is in the white light imaging mode;
a third filter configured to permit passage of optical signals, responsive to illumination of the target surface with the white light and having a wavelength in the visible light range, the third filter being fixed to the third image sensor; and
a processor configured to receive the detected fluorescent and white light optical signals and to output a representation of the target surface to a display based on the detected optical signals.