US 12,245,790 B2
Method for painless renal denervation using a peri-vascular tissue ablation catheter with support structures
David R. Fischell, Fair Haven, NJ (US); Tim A. Fischell, Kalamazoo, MI (US); Robert Ryan Ragland, Temecula, CA (US); Darrin James Kent, Murrieta, CA (US); Andy Edward Denison, Temecula, CA (US); Eric Thomas Johnson, Temecula, CA (US); Jeff Alan Burke, Winchester, CA (US); Christopher Scott Hayden, Winchester, CA (US); and Robert E. Fischell, Dayton, MD (US)
Assigned to Ablative Solutions, Inc., Wakefield, MA (US)
Filed by Ablative Solutions, Inc., San Jose, CA (US)
Filed on Aug. 4, 2020, as Appl. No. 16/984,690.
Application 16/984,690 is a continuation of application No. 16/296,688, filed on Mar. 8, 2019, granted, now 10,736,656.
Application 16/296,688 is a continuation of application No. 14/841,662, filed on Aug. 31, 2015, granted, now 10,226,278, issued on Mar. 12, 2019.
Application 14/841,662 is a continuation in part of application No. 14/266,726, filed on Apr. 30, 2014, granted, now 9,526,827, issued on Dec. 27, 2016.
Application 14/266,726 is a continuation in part of application No. 13/752,062, filed on Jan. 28, 2013, granted, now 8,740,849, issued on Jun. 3, 2014.
Claims priority of provisional application 61/719,906, filed on Oct. 29, 2012.
Prior Publication US 2021/0015518 A1, Jan. 21, 2021
Int. Cl. A61B 17/34 (2006.01); A61B 18/00 (2006.01); A61B 18/04 (2006.01); A61B 18/06 (2006.01); A61B 18/14 (2006.01); A61B 90/00 (2016.01); A61M 25/00 (2006.01); A61M 25/10 (2013.01)
CPC A61B 17/3403 (2013.01) [A61B 17/3478 (2013.01); A61B 18/00 (2013.01); A61B 18/04 (2013.01); A61B 18/06 (2013.01); A61B 18/1492 (2013.01); A61M 25/0084 (2013.01); A61B 2018/00214 (2013.01); A61B 2018/00267 (2013.01); A61B 2018/00279 (2013.01); A61B 2018/00404 (2013.01); A61B 2018/00434 (2013.01); A61B 2018/00511 (2013.01); A61B 2018/00517 (2013.01); A61B 2018/00577 (2013.01); A61B 2018/046 (2013.01); A61B 2018/143 (2013.01); A61B 2018/1432 (2013.01); A61B 2018/1475 (2013.01); A61B 2090/3966 (2016.02); A61B 2218/002 (2013.01); A61M 2025/0087 (2013.01); A61M 25/10 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A transvascular method of minimizing pain during the treatment of extravascular tissue, comprising:
providing a catheter having an elongate flexible body, a proximal end, a distal end, and a needle disposed within a lumen of a guide tube;
transvascularly positioning the distal end of the catheter at a treatment site;
deploying the needle into a vessel wall at a depth of more than 0.5 mm from an inside surface of the vessel wall while maintaining the guide tube against the vessel wall, without the guide tube puncturing the vessel wall;
a single injection of an ablative agent with a first flow rate for desensitizing pain nerves by injecting the ablative agent through the needle wherein the ablative fluid spreads out both radially and circumferentially and a second flow rate for ablating sympathetic nerves by injecting the ablative agent through the needle.