	US 12,245,623 B2
	Olive oil enriched with oleanolic acid, process for its preparation and use thereof
Jose Maria Castellano Orozco, Seville (ES); Mirela Rada, Seville (ES); Angeles Guinda Garin, Seville (ES); Jose Manuel Santos Lozano, Seville (ES); and Jose Lapetra Peralta, Seville (ES)
Assigned to CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS (CSIC), Madrid (ES); and SERVICIO ANDALUZ DE SALUD, Seville (ES)
Appl. No. 17/258,588
Filed by CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS (CSIC), Madrid (ES); and SERVICIO ANDALUZ DE SALUD, Seville (ES)
PCT Filed Jul. 8, 2019, PCT No. PCT/EP2019/068199 § 371(c)(1), (2) Date Jan. 7, 2021, PCT Pub. No. WO2020/011689, PCT Pub. Date Jan. 16, 2020.
Claims priority of application No. 18382510 (EP), filed on Jul. 9, 2018.
Prior Publication US 2021/0227867 A1, Jul. 29, 2021
Int. Cl. A23L 33/115 (2016.01); A61K 9/00 (2006.01); A61K 9/10 (2006.01); A61K 31/56 (2006.01); A61K 36/63 (2006.01); A61P 3/10 (2006.01); B82Y 5/00 (2011.01); B82Y 40/00 (2011.01)

CPC A23L 33/115 (2016.08) [A61K 9/0053 (2013.01); A61K 9/10 (2013.01); A61K 31/56 (2013.01); A61K 36/63 (2013.01); A61P 3/10 (2018.01); B82Y 5/00 (2013.01); B82Y 40/00 (2013.01)]

11 Claims

1. An olive oil comprising a starting olive oil enriched with crystalized oleanolic acid (OA) characterized in that a concentration of the crystalized oleanolic acid in said starting olive oil, including the crystalized oleanolic acid formed as glycosylated derivatives and esters, is comprised between 580 and 650 mg/kg, wherein the starting olive oil is virgin olive oil, extra virgin olive oil, refined olive oil or mixtures thereof, wherein the crystalized OA comprises OA nanoparticles having a size between 90 and 300 nm at a concentration between 6000 and 6600 mg/kg, wherein the OA nanoparticles exist in a diluted volume ratio of a nanosuspension to the starting olive oil being between 1:7 and 1:15.