US 11,921,181 B2
High-resolution cerebrospinal fluid-suppressed T2*-weighted magnetic resonance imaging of cortical lesions
Daniel Salo Reich, Bethesda, MD (US); Erin Savner Beck, Bethesda, MD (US); Govind Nair, Bethesda, MD (US); and Neville Dali Gai, Bethesda, MD (US)
Assigned to THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES, Bethesda, MD (US)
Appl. No. 17/593,365
Filed by Daniel Salo Reich, Bethesda, MD (US); Erin Savner Beck, Bethesda, MD (US); Govind Nair, Bethesda, MD (US); and Neville Dali Gai, Bethesda, MD (US)
PCT Filed Apr. 24, 2020, PCT No. PCT/US2020/029823
§ 371(c)(1), (2) Date Sep. 16, 2021,
PCT Pub. No. WO2020/219886, PCT Pub. Date Oct. 29, 2020.
Claims priority of provisional application 62/838,578, filed on Apr. 25, 2019.
Prior Publication US 2022/0268867 A1, Aug. 25, 2022
Int. Cl. G01V 3/00 (2006.01); A61B 5/00 (2006.01); A61B 5/055 (2006.01); G01R 33/56 (2006.01); G01R 33/563 (2006.01); G01R 33/565 (2006.01)
CPC G01R 33/5607 (2013.01) [A61B 5/0042 (2013.01); A61B 5/055 (2013.01); G01R 33/5602 (2013.01); G01R 33/5608 (2013.01); G01R 33/56341 (2013.01); G01R 33/56509 (2013.01)] 36 Claims
OG exemplary drawing
 
1. A method of visualizing a cortical lesion in a subject using a magnetic resonance imaging (MRI) system, comprising:
(a) acquiring signal data with the MRI system by performing a T2*-weighted sequence, wherein the sequence suppresses cerebrospinal fluid (CSF) signals; and,
(b) from the signal data, producing one or more high resolution images, at a computer system of the MRI system, indicative of the presence of the cortical lesion, for direct visualization of the cortical lesion,
wherein the T2*-weighted sequence comprises a T2-prepared inversion pulse (T2Prep) followed by an inversion pulse, wherein the T2Prep suppresses CSF signals.