US 11,920,195 B2
Method for diagnosing drug addiction, method for screening therapeutic agent for drug addiction and pharmaceutical composition for preventing or treating drug addiction
Heh-In Im, Seoul (KR); Baek Sun Kim, Seoul (KR); and Sung Hyun Tag, Seoul (KR)
Assigned to Korea Institute of Science and Technology, Seoul (KR)
Filed by KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY, Seoul (KR)
Filed on May 28, 2021, as Appl. No. 17/334,345.
Claims priority of application No. 10-2020-0077727 (KR), filed on Jun. 25, 2020; and application No. 10-2021-0047804 (KR), filed on Apr. 13, 2021.
Prior Publication US 2021/0403996 A1, Dec. 30, 2021
Int. Cl. C12Q 1/6876 (2018.01); C12Q 1/686 (2018.01)
CPC C12Q 1/6876 (2013.01) [C12Q 1/686 (2013.01); C12Q 2600/178 (2013.01)] 7 Claims
 
1. A method for screening a therapeutic agent for drug addiction, comprising a) inducing drug addiction in an animal and treating the drug-addicted animal or a biological sample separated therefrom with a candidate agent; b) measuring the synaptotagmin binding cytoplasmic RNA interacting protein (SYNCRIP) gene or its expression level in the candidate agent-treated animal or biological sample, and c) selecting the candidate agent as a therapeutic agent for drug addiction if the measured expression level of the SYNCRIP gene is higher than that in a control group untreated with the candidate agent.