	US 11,920,138 B2
	Fusion proteins and methods thereof
Antonio Iavarone, New York, NY (US); Anna Lasorella, New York, NY (US); and Raul Rabadan, New York, NY (US)
Assigned to THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, New York, NY (US)
Filed by The Trustees of Columbia University in the City of New York, New York, NY (US)
Filed on Jul. 10, 2019, as Appl. No. 16/507,977.
Application 16/507,977 is a continuation of application No. 14/604,530, filed on Jan. 23, 2015, abandoned.
Application 14/604,530 is a continuation in part of application No. PCT/US2013/051888, filed on Jul. 24, 2013.
Claims priority of provisional application 62/096,311, filed on Dec. 23, 2014.
Claims priority of provisional application 61/675,006, filed on Jul. 24, 2012.
Prior Publication US 2020/0033353 A1, Jan. 30, 2020
Int. Cl. C12N 15/62 (2006.01); C07K 14/47 (2006.01); C07K 14/71 (2006.01); C07K 14/82 (2006.01); C07K 16/18 (2006.01); C07K 16/28 (2006.01); C12N 9/12 (2006.01); C12Q 1/6886 (2018.01); G01N 33/574 (2006.01)

CPC C12N 15/62 (2013.01) [C07K 14/47 (2013.01); C07K 14/71 (2013.01); C07K 14/82 (2013.01); C07K 16/18 (2013.01); C07K 16/2863 (2013.01); C12N 9/12 (2013.01); C12Q 1/6886 (2013.01); G01N 33/57492 (2013.01); C07K 2319/00 (2013.01); C07K 2319/73 (2013.01); C12Q 2600/158 (2013.01); G01N 2333/91205 (2013.01)]

26 Claims

1. A synthetic polynucleotide comprising a polynucleotide sequence complementary to a portion of a polynucleotide sequence encoding a breakpoint between a FGFR1 portion and a TACC1 portion of a FGFR1-TACC1 fusion protein or a complement thereof, or a breakpoint between a FGFR3 portion and a TACC3 portion of a FGFR3-TACC3 fusion protein or a complement thereof, wherein the synthetic polynucleotide further comprises a chemical modification, wherein the chemical modification comprises a radioactive molecule, a fluorescent molecule, a chemiluminescent molecule, an enzyme, or an affinity molecule.