US 11,920,118 B2
Method for fabricating highly elastic porous polymer membrane, method for manufacturing cell culture system using porous polymer membrane fabricated by the fabrication method and cell culture system manufactured by the manufacturing method
Young Mee Jung, Seoul (KR); Soo Hyun Kim, Seoul (KR); Justin Jihong Chung, Seoul (KR); Jin Yoo, Seoul (KR); and Tae Hee Kim, Seoul (KR)
Assigned to Korea Institute of Science and Technology, Seoul (KR)
Filed by KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY, Seoul (KR)
Filed on Oct. 27, 2020, as Appl. No. 17/081,723.
Claims priority of application No. 10-2020-0038224 (KR), filed on Mar. 30, 2020.
Prior Publication US 2021/0301241 A1, Sep. 30, 2021
Int. Cl. C12M 1/00 (2006.01)
CPC C12M 29/04 (2013.01) [C12M 23/26 (2013.01)] 9 Claims
OG exemplary drawing
 
1. A method for fabricating a porous polymer membrane, comprising:
mixing a biodegradable elastomeric polymer with a water-soluble moisture absorbent in an organic solvent to prepare a mixture solution; and
applying the mixture solution to a substrate in a closed chamber, followed by spin coating at a relative humidity of 65 to 90%,
wherein the biodegradable elastomeric polymer is poly(L-lactide-co-caprolactone),
wherein a molar ratio of the L-lactide to the caprolactone in the poly(L-lactide-co-caprolactone) is 1-9:9-1,
wherein the poly(L-lactide-co-caprolactone) has
a number average molecular weight (Mn) of 50,000 to 500,000 g/mol, and
a weight average molecular weight (Mw) of 50,000 to 800,000 g/mol,
wherein a strain of the porous polymer membrane is 30 to 60% at a stretching temperature of 20 to 40° C.