	US 11,919,941 B2
	Cell-collagen-silica composites and methods of making and using the same
Jenna Leigh Rickus, West Lafayette, IN (US); Sherry L. Voytik-Harbin, Zionsville, IN (US); and Jennifer L. K. Rich, West Lafayette, IN (US)
Assigned to Purdue Research Foundation, West Lafayette, IN (US)
Appl. No. 15/568,262
Filed by Purdue Research Foundation, West Lafayette, IN (US)
PCT Filed Apr. 21, 2016, PCT No. PCT/US2016/028686 § 371(c)(1), (2) Date Oct. 20, 2017, PCT Pub. No. WO2016/172365, PCT Pub. Date Oct. 27, 2016.
Claims priority of provisional application 62/150,439, filed on Apr. 21, 2015.
Prior Publication US 2018/0141996 A1, May 24, 2018
Int. Cl. C07K 14/78 (2006.01); C12N 5/00 (2006.01); C12N 5/071 (2010.01); C12N 11/04 (2006.01); C12N 11/14 (2006.01)

CPC C07K 14/78 (2013.01) [C12N 5/0012 (2013.01); C12N 5/0697 (2013.01); C12N 11/04 (2013.01); C12N 11/14 (2013.01)]

28 Claims

1. A composition comprising:

a crosslinked polymerized oligomeric collagen network wherein the crosslinks consist of natural intermolecular crosslinks, and

a porous condensed silica layer formed on the polymerized oligomeric collagen only at the surface of the outermost layer of the collagen network.