US 11,919,915 B2
Compounds and methods useful for stabilizing phenylalanine hydroxylase mutations
Lucrezia De Pascalis, Cambridge, MA (US); Heather Jane Finlay, Skillman, NJ (US); Sandra King, Jamaica Plain, MA (US); Zenon D. Konteatis, Chatham Township, NJ (US); and Brian C. Shook, Holliston, MA (US)
Assigned to Agios Pharmaceuticals, Inc., Cambridge, MA (US)
Filed by Agios Pharmaceuticals, Inc., Cambridge, MA (US)
Filed on Jun. 27, 2023, as Appl. No. 18/214,831.
Application 18/214,831 is a continuation of application No. 18/114,635, filed on Feb. 27, 2023.
Claims priority of provisional application 63/314,580, filed on Feb. 28, 2022.
Prior Publication US 2023/0339980 A1, Oct. 26, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. C07D 519/00 (2006.01)
CPC C07D 519/00 (2013.01) 30 Claims
 
1. A compound of Formula I-B-1:

OG Complex Work Unit Chemistry
or tautomer thereof, or a pharmaceutically acceptable salt of the compound or tautomer, wherein:
R1 is

OG Complex Work Unit Chemistry
x is 0 to 5;
each Ra independently is halo, C1-6alkyl, C3-6cycloalkyl, C1-6haloalkyl, C1-6alkoxy or C1-6haloalkoxy;
R2 is

OG Complex Work Unit Chemistry
R5 is H or D; and
R6 is optionally substituted heteroaryl.